Volume 36 (2022) – Issue 2-3 – Article 1 – Review of Clinical Pharmacology and Pharmacokinetics – International Edition

Open Access-Title

Study of the cosmetic properties of microalgae extracts – The case of Nannochloropsis oculata

Author

Angeliki Liakopoulou, Soultana Mountsaki, Vasilis Andriopoulos, Maria Gkioni, Michael Kornaros, Fotini Lamari and Sophia Hatziantoniou

Department of Pharmacy, School of Health Sciences, University of Patras, 26504 Patras, Greece

Department of Chemical Engineering, School of Engineering, University of Patras, 26504 Patras, Greece

Citation

Angeliki Liakopoulou, Soultana Mountsaki, Vasilis Andriopoulos, Maria Gkioni, Michael Kornaros, Fotini Lamari and Sophia Hatziantoniou. Study of the cosmetic properties of microalgae extracts – The case of Nannochloropsis oculata. Review Clin. Pharmacol. Pharmacokinet. 2023, 36, 2-3, 31-36. DOI:10.5281/zenodo.10211529

Publication Date
Republication Date
04-08-2022
27-11-2023
Full Text Language

English

DOI:10.5281/zenodo.10211529

Keywords
microalgae; Nannochloropsis oculata; cosmetics; UV filters; transepidermal water loss, skin hydration
Other Terms

Research Article

Summary
Microalgae are an exceptional source of bioactive compounds which during the recent years have found applications as active ingredients in cosmetic prod-ucts. The aim of this study was to investigate the pos-sibility of using microalgae extracts in cosmetic formu-lations. For this purpose, the sun protection factor (SPF) of Tisochrysis lutea, Nannochloropsis oculata, Isochrysis galbana, Dunaliella salina, and Chlorella minutissima extracts were evaluated in vitro. Addition-ally, the effect of Nannocloropsis oculata (NO) extract on skin barrier and hydration was also assessed on healthy volunteers.
The results suggested that the maximum SPF (~30) was achieved by Tisochrysis lutea and Chlorella minutissima extracts. Medium SPF (~20-25) was cal-culated for Isochrysis galbana and Dunaliella salina ex-tracts, while Nannochloropsis oculata extract did not exceed SPF 12,5.
The in vivo study showed that the incorporation of Nannochloropsis oculata extract in a cream did not contribute to the improvement of the disturbed skin barrier, however it caused a significant increase of skin hydration at least one hour after its application.
In conclusion, these findings suggest the ability of NO extract to affect some basic features of skin proper-ties, offering new insights into the beneficial role of bioactive microalgae compounds in cosmetic formula-tions.
References 1. Baby, A. R., & Morocho-Jácome, A. L. Dermocosmetic applications of microalgal pigments. Advances in Applied Microbiology, 117, 63–93 (2021).
2. Morocho-Jácome, A. L., Dos Santos, B. B., de Car-valho, J. C. M., de Almeida, T. S., Rijo, P., Velasco, M. V. R., Rosado, C., & Baby, A. R. Microalgae as a Sustaina-ble, Natural-Oriented and Vegan Dermocosmetic Bioac-tive Ingredient: The Case of Neochloris oleoabundans. Cosmetics, 9(1) (2022).
3. Mourelle, M. L., Gómez, C. P., & Legido, J. L. The potential use of marine microalgae and cyanobacteria in cosmetics and thalassotherapy. Cosmetics, 4(4) (2017).
4. Bhalamurugan, G. L., Valerie, O., & Mark, L.. Valuable bioproducts obtained from microalgal biomass and their commercial applications: A review. Environmental Engi-neering Research, 23(3), 229–241 (2018).
5. Kim, S. Y., Kwon, Y. M., Kim, K. W., & Kim, J. Y. H. Exploring the potential of nannochloropsis sp. Extract for cosmeceutical applications. Marine Drugs, 19(12) (2021).
6. Letsiou, S., Kalliampakou, K., Gardikis, K., Mantecon, L., Infante, C., Chatzikonstantinou, M., Labrou, N. E., & Flemetakis, E. Skin protective effects of Nannochloropsis gaditana extract on H2O2-stressed human dermal fibro-blasts. Frontiers in Marine Science, 4(JUL), 1–15 (2017).
7. Salbitani, G., Del Prete, F., Carfagna, S., Sansone, G., & Barone, C. M. A. Enhancement of pigments pro-duction by nannochloropsis oculata cells in response to bicarbonate supply. Sustainability (Switzerland), 13(21), 1–8 (2021).
8. Yarkent Ç, Oncel SS. Recent Progress in Microalgal Squalene Production and Its Cosmetic Application. Bio-technol Bioprocess Eng. 27(3):295-305 (2022).
9. Udayan, A., Pandey, A. K., Sirohi, R., Sreekumar, N., Sang, B. I., Sim, S. J., Kim, S. H., & Pandey, A. Produc-tion of microalgae with high lipid content and their poten-tial as sources of nutraceuticals. Phytochemistry Reviews, 0123456789 (2022).
10. Ariede, M. B., Candido, T. M., Jacome, A. L. M., Velasco, M. V. R., de Carvalho, J. C. M., & Baby, A. R.. Cosmetic attributes of algae – A review. Algal Research, 25(May), 483–487 (2017)
11. Kim, S. K., Ravichandran, Y. D., Khan, S. B., & Kim, Y. T. Prospective of the cosmeceuticals derived from marine organisms. Biotechnology and Bioprocess Engi-neering, 13(5), 511–523 (2008).
12. Prestat-Marquis, E. Non-invasive in vivo methods to measure lipidic formulae efficacy at the skin surface: Advantages and limits. OCL – Oilseeds and Fats, Crops and Lipids, 25(5) (2018).
13. Andriopoulos, V.; Gkioni, M.D.; Koutra, E.; Mastropetros, S.G.; Lamari, F.N.; Hatziantoniou, S.; Kor-naros, M. Total Phenolic Content, Biomass Composition, and Antioxidant Activity of Selected Marine Microalgal Species with Potential as Aquaculture Feed. Antioxidants 11, 1320. (2022).
14. Gkioni, M. D., Andriopoulos, V., Koutra, E., Hatzi-antoniou, S., Kornaros, M., & Lamari, F. N. Ultrasound-Assisted Extraction of Nannochloropsis oculata with Eth-anol and Betaine: 1, 2-Propanediol Eutectic Solvent for Antioxidant Pigment-Rich Extracts Retaining Nutritious the Residual Biomass (2022).
15. Roy, A., Sahu, R., Matlam, M., Deshmukh, V., Dwivedi, J., & Jha, A. In vitro Techniques To assess the proficiency of skin care cosmetic formulations. Pharma-cognosy Reviews, 7(14), 97–106 (2013).
16. Wolf, M., Klang, V., Stojcic, T., Fuchs, C., Wolzt, M., & Valenta, C. NLC versus nanoemulsions: Effect on physiological skin parameters during regular in vivo appli-cation and impact on drug penetration. International Journal of Pharmaceutics, 549(1–2), 343–351 (2018).
17. Alexander, H., Brown, S., Danby, S., & Flohr, C. (2018). Research Techniques Made Simple: Transepi-dermal Water Loss Measurement as a Research Tool. Journal of Investigative Dermatology, Journal of Investi-gative Dermatology 138, 2295e2300 (2018)
18. Constantin, M. M., Poenaru, E., Poenaru, C., & Con-stantin, T. Skin Hydration Assessment through Modern Non-Invasive Bioengineering Technologies. Maedica, 9(1), 33–38 (2014).
19. Kim, J. H., Lee, J. E., Kim, K. H., & Kang, N. J. Bene-ficial effects of marine algae-derived carbohydrates for skin health. Marine Drugs, 16(11), 1–20 (2018).20. Aya, P. A. V., & Torres, G. R. Sunscreen and moist-urizer cream effects of cosmetic formulations containing extracts of Hypnea musciformis collected in the Colombi-an Caribbean. Pharmacy & Pharmacology International Journal, 8(3), 192–199 (2020).
21. Stoyneva-Gärtner, M., Uzunov, B., & Gärtner, G. Enigmatic microalgae from aeroterrestrial and extreme habitats in cosmetics: The potential of the untapped natural sources. Cosmetics, 7(2), 1–22 (2020).
22. Thiyagarasaiyar, K., Goh, B. H., Jeon, Y. J., & Yow, Y. Y. Algae metabolites in cosmeceutical: An overview of current applications and challenges. Marine Drugs, 18(6) (2020).
23. Vega, J., Bonomi-Barufi, J., Gómez-Pinchetti, J. L., & Figueroa, F. L. Cyanobacteria and Red Macroalgae as Potential Sources of Antioxidants and UV Radiation-Absorbing Compounds for Cosmeceutical Applications. Marine Drugs, 18(12) (2020).
24. He H, Li A, Li S, Tang J, Li L, Xiong L. Natural com-ponents in sunscreens: Topical formulations with sun protection factor (SPF). Biomed Pharmacother. Feb; 134:111161 (2021).
25. Kelchen, M. N., Menon, G., Eyck, P. Ten, Prettypaul, D., Nicole, K., City, I., City, I., & City, I. Creams on Epi-dermal Responses. 31(5), 319–335(2019).
26. De Luca, M., Pappalardo, I., Limongi, A. R., Viviano, E., Radice, R. P., Todisco, S., Martelli, G., Infantino, V., & Vassallo, A. Lipids from microalgae for cosmetic appli-cations. Cosmetics, 8(2) (2021).
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