|
Open Access- Title
|
Genetic polymorphisms possibly implicated in Diabetes Mellitus |
|
|
Author
|
Maria Trapali and Anna Papadopoulou Department of Biomedical Sciences, School of Health and Caring, West Attica University (UniWA) |
|
|
Citation
|
M. Trapali and A. Papadopoulou. Genetic polymorphisms possibly implicated in Diabetes Mellitus. Rev. Clin. Pharmacol. Pharmacokinet., Int. Ed. 37 (1) 43-48 (2023). DOI: 10.5281/zenodo.10029552
|
|
|
Publication Date
Republication Date
|
28-02-2023
21-10-2023
|
|
|
Full Text Language
|
English |
|
|
DOI: 10.5281/zenodo.10029552 |
||
|
Keywords
|
Diabetes mellitus, polymorphisms, LPL gene, TNF-α promoter, metallothionein, Nitric Oxide Synthase
|
|
|
Other Terms
|
Review |
|
|
Summary
|
Diabetes mellitus refers to a group of diseases that affect how the body uses blood sugar (glucose). Glucose is an important source of energy for the cells that make up the muscles and tissues. It’s also the brain’s main source of fuel. Many genetic polymorphisms are possibly implicated in Diabetes Mellitus. The main polymorphisms are Single-nucleotide polymorphism (-308G>A) in the TNF-α promoter, S477X polymorphism of LPL gene, A6244G polymorphism of IRS-1 gene, Polymorphisms in metallothionein-1and 2 genes, Polymorphisms in genes encoding adiponectin (ADIPOQ) and interleukin-6 (IL6), G Protein β3 Gene Variant, Endothelial Nitric Oxide Synthase Gene Polymorphisms, Estrogen receptor alpha gene and Renin-angiotensin aldosterone system gene polymorphisms. | |
| References | Dutta, D. et al., 2013. Diabetes Research and Clinical practice. Tumor necrosis factor alpha S238G/A (rs 361525) gene polymorphism predicts progression to type-2 diabetes in an Eastern Indian population with prediabetes, 99, e37-e41. Jamil, K. et al., 2015. Saudi Journal of Biological Sciences, 24, 1195-1203. Perez-Luque, E., Malacara, J. M., Garay-Sevilla, E. & Fajardo, M. E., 2012. Association of the TNF-α −308G/A polymorphism with family history of type 2 diabetes mellitus in a Mexican population. Clinical Biochemistry, 45,12-15. Rodrıguez-Perez, J. ́. et al., 2001. Association of angiotensinogen m235t and a(-6)g gene polymorphisms with coronary heart disease with independence of essential hypertension: the procagene study. Journal of the American College of Cardiology, 37(6),1536–42. Achyut, B., Srivastava, A., Bhattacharya, S. & Mittal, B., 2007. Genetic association of interleukin-1β (−511C/T) and interleukin-1 receptor antagonist (86 bp repeat) polymorphisms with Type 2 diabetes mellitus in North Indians. Clinica Chimica Acta , 377, 163–169. Akhter, M. et al., 2022. Endothelial Nitric Oxide Synthase Gene Polymorphisms Increase Risk of Deep Vein Thrombosis by Altering Homocysteine Levels. Clin Lab., 1, 68(3). Dai, H. et al., 2021. Metallothionein 1: A New Spotlight on Inflammatory Diseases. Front. Immunol., 12,739918. De Oliveira, R. d. et al., 2015. ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction. Diabetology & Metabolic Syndrome, 7, 34. Eregat, S., Caushi, S., Eweidat, K. & Nasereddin, A., 2019. Estrogen receptor 1 gene polymorphisms (PvuII and XbaI) are associated with type 2 diabetes in Palestinian women. PeerJ, 7, e7164. Fernández-Real, J. M. et al., 2013. G Protein β3 Gene Variant, Vascular Function, and Insulin Sensitivity in Type 2 Diabetes. Hypertension, 41, 124-129. Ghazouani, L. et al., 1995. -308G>A and 1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease. Journal of Clinical Investigation, 96, 3005-3008. Hotamisligil , G., 1999. The role of TNFα and TNF receptors in obesity and insulin resistance. Journal of Internal Medicine, 245, 621-625. Ismail, J. M., Hussain, M. K. & Mohammad, H. J., 2016. ASSOCIATION OF ADIPONECTIN GENE POLYMORPHISM rs266729 WITH ADIPONECTIN LEVELS IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT CVD. IN AL-NAJAF GOVERNORATE IRAQ. International Journal of Advanced Research, 4, 1089-1096. Motawi , T. et al., 2015. Genetic polymorphism of estrogen receptor alpha gene in Egyptian women with type II diabetes mellitus. Meta Gene, 6, 36–41. Rezuan, A. M. et al., 2021. Prevalence of single-nucleotide polymorphism (-308G>A) in the TNF-α promoter region correlates coronary heart disease among type-2 diabetic patients from the northern region of Bangladesh. J Adv Biotechnol Exp Ther, 4(1), 60-66. Sbarsi, I. et al., 2007. Inflammation and atherosclerosis: the role of TNF and TNF receptors polymorphisms in coronary artery disease.. International Journal of Immunopathology and Pharmacology, 20, 145-154. Shoukry, A. et al., 2012. Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Diabetic Nephropathy in Type 2 Diabetes Mellitus. GENETIC TESTING AND MOLECULAR BIOMARKERS, 16(6), 574–579. Tian, B., Nowak, D. & Brasier, A., 2005. A TNF-induced gene expression program under oscillatory NF-κB control. BMC Genomics, 6, 137. Trapali, M. et al., 2022. Association of TNF-α- 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus. Genes, 13,59. Trapali, M., Papadopoulou, A. & Karkalousos, P., 2022. Effects of Diabetes Mellitus upon Sperm Quality. Journal of Diabetes Mellitus, 12,75-86. Vasudevan, R., Johnson, S., Patimah, I. & Norashikin, S., 2009. Analysis of three genetic polymorphisms in Malaysian essential hypertensive and type 2 diabetic subjects. African Journal of Biotechnology, pp. 8 (10), 2069-2075. Yang, L. et al., 2008. Polymorphisms in metallothionein-1and 2 genes associated with the risk of type. Am J Physiol Endocrinol Metab, p. doi:10.1152/ajpendo.90234.2008 . Zhang, H. et al., 2011. Tumor necrosis factor-alpha G-308A gene polymorphism and coronary heart disease susceptibility: an updated meta-analysis. Thrombosis Research, 127, 400-405. |
|
|
Relative Papers
|