|
Open Access – Title
|
The role of parabens in diabetes |
|
|
Author
|
Ioannis Syrmaloglou, Maria Trapali Cosmetic Laboratory BEAUTY COSM |
|
|
Citation
|
Syrmaloglou, M. Trapali. The role of Parabens in Diabetes. Review Clin. Pharmacol. Pharmacokinet. 2023, 37, 2, 89-93. DOI: 10.5281/zenodo.8398735 |
|
|
Publication Date
|
02-10-2023
|
|
|
Full Text Language
|
English |
|
|
Open access article
DOI: 10.5281/zenodo.8398735 |
||
|
Keywords
|
parabens, diabetes, glucose metabolism
|
|
|
Other Terms
|
Review |
|
|
Summary
|
Parabens are esters of p-hydroxybenzoic acid and have been used as preservatives for personal care products, pharmaceuticals, cosmetics, and foods attributable to their anti-microbial and anti-fungal properties. Diabetes mellitus is a metabolic disease characterized by an increase in the concentration of sugar in the blood [hyperglycemia] and a disturbance of glucose metabolism, either as a result of decreased insulin secretion or due to a decrease in the sensitivity of the body’s cells to insulin. It has been found association between urinary paraben levels in early pregnancy and Gestational diabetes. The purpose of the review is the association between parabens and diabetes. While previous studies have assessed the association between endocrine disruptors and conditions that are often comorbid with or predispose to diabetes, the literature lacks large population studies examining the association with diabetes. However, studies showed that butylparaben concentrations were positively associated with glucose levels, propylparaben concentrations negatively associated with glucose levels in pregnant women. | |
| References | 1. Oxidic degradation of lipids in patients with type II diabetes [2021] Μ. Trapali Review of Clinical Pharmacology and Pharmacokinetics, 35[2] #-4 2. Serum Lipids and Lipokines as Prognostic/Diagnostic Biomarkers in Common Cancers [2022] N. Dogkas, M. Τrapali, C. Fountzoula, G. Karikas, P. Karkalousos Journal of Diabetes Mellitus,12,122-140 3. Antioxidant Activity in Patients with Type II Diabetes [2022] M. Trapali Review of Clinical Pharmacology and Pharmacokinetics, 36[1],6 4. Effects of Diabetes Mellitus upon Sperm Quality Insight into Molecular Level [2022] A. Papadopoulou, P. Karkalousos, M. Trapali, Journal of Diabetes Mellitus, 12, 75-86. https://doi.org/10.4236/jdm.2022.122008 5. Genetic polymorphisms possibly implicated in Diabetes Mellitus [2023] M. Trapali, A. Papadopoulou Review of Clinical Pharmacology and Pharmacokinetics, 37[1]: 1-6 6. Association of TNF-α- 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus [2022] M. Trapali, D. Houhoula, A. Batrinou, A. Kanellou, I. Strati, A. Siatelis and P. Halvatsiotis, Genes, 13, 59. https://doi.org/ 10.3390/genes13010059 7. PAF- ACETYLHYDROLASE activity and PAF levels in pancreas and plasma of diabetic, fasted and well-fed rat [1996] M. Trapali, M. Mavri – Vavayanni, A. Siafaka – Kapadai. Life Sciences.59. No.10, 849 – 857 8. Lipidic classes involved in Diabetes mellitus, Review [2021] A. Bourkoula, E. Konsta, A. Papadopoulou and Maria Trapali Nov Res Sci. NRS. 000685.DOI: 10.31031/NRS.2021.08.000685 9. Effect of sibutramine on regional fat pads and leptin levels in rats fed with three isocaloric diets [2008] T. Stroubini, D. Perrea, A. Perelas, C. Liapi, I. Dontas, M. Trapali, N. Katsilambros, P. Galanopoulou1 Eur. Cytokine Netw., 19, 149-55 10. Effects of sibutramine treatment on food intake, body weight, lipid profile and TNF-α in serum and epididymal fat of rats fed with high fat diet [2005]: P136 M. Trapali, C. Liapi, I. Donts, M. Mavri, N. Katsilabros, P, Galanopoulou Obesity Reviews 6 11. Effect of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-alpha levels in rats [2008] M. Trapali , C. Liapi, A. Perelas, D. Perrea, T. Stroubini, I. Dontas, E. Couvari, M. Mavri, P. Galanopoulou Pharmacology.82[1],15-21. doi: 10.1159/000127363. 12. Sibutramine reduces food intake and Body Weight-increasing rate of rats fed a long-term High Fat Diet independently of serum TNF-α levels [2006] M. Trapali, Th. Stroubini, C. Liapi, I. Dontas, D. Perrea, K. Marinou, M. Mavri and P. Galanopoulou Review of Clinical Pharmacology and Pharmacokinetics, 20, 117-119 13. Effects of sibutramine treatment on food intake, serum lipoproteins and TNF-α levels in rats fed standard laboratory or three isocaloric diets [2008]. T. Stroubini, A. Perelas, Charis Liapi, D. Perrea, I. Dontas, M. Trapali, P. Galanopoulou. Review of Clinical Pharmacology and Pharmacokinetics, 22, 339-342 14. Parabens exposure in early pregnancy and gestational diabetes mellitus [2019] W. Liua, , Y. Zhoub, J.Lib , X. Suna , H. Liua , Y. Jianga , Y.Penga , H. Zhaob , W. Xiaa , Y. Lia , Z. Caib, S. Xua, Environment International, 126,468-475 15. Urinary concentrations of parabens mixture and pregnancy glucose levels among women from a fertility clinic [2018] A. Bellavia, Y.H. Chiu, F.M. Brown, L. Minguez-Alarcon, J.B. Ford, M. Keller, J. Petrozza, P.L. Williams, X. Ye, A.M. Calafat, R. Hauser, T. James-Todd, E.S. Team Environ. Res., 168, 389-396 16. Association of urinary phthalate metabolites and phenolics with adipokines and insulin resistance related markers among women of reproductive age [2019] I. Lee, S. Kim, S. Park, S. Mok, Y. Jeong, H.B. Moon, J. Lee, S. Kim, H.J. Kim, G. Choi, S. Choi, S.Y. Kim, A. Lee, J. Park, S. Choi Sci. Total Environ., 688, 1319-1326 17. Influence of vegetarian dietary intervention on urinary paraben concentrations: a pilot study with ‘Temple Stay’ participants [2020] A. Jo, S. Kim, K. Ji, Y. Kho, K. Choi Toxics, 8 [1], 3 18. Associations of urinary concentrations of phthalate metabolites, bisphenol A, and parabens with obesity and diabetes mellitus in a Korean adult population: Korean National Environmental Health Survey [KoNEHS] 2015–2017 [2021] I. Lee, Y. Park, M. Kim, S. Kim, S. Choi, J.Park, Y. Hee Cho , S. Hong, J. Yoo , H. Park, G. Cheon , K. Choi, M. Kyong Moon Environment International, 146,106227 19. Urinary phenols and parabens and diabetes among US adults, NHANES 2005-2014 [2020] J. Ward, S. Casagrande, C. Cowie Nutr Metab Cardiovasc Dis., 30(5),768–776 doi: 10.1016/j.numecd.2020.01.005 20. Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A. [2005] A. Zsarnovszky, HH Le, HS Wang,SM Belcher Endocrinology,146,5388–96. 21. How ERK1/2 Activation Controls Cell Proliferation and Cell Death Is Subcellular Localization the Answer? [2009] Y. Mebratu, Y. Tesfaigzi Cell Cycle, 15, 8(8), 1168–1175 doi: 10.4161/cc.8.8.8147 |
|
|
Relative Papers
|
||