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Open Access-Title
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Oxidic Degradation of Lipids in Patients with Type II Diabetes |
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Author
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Maria Trapali Laboratory of Chemistry, Biochemistry, Cosmetic Science, Department of Medical Laboratories, University of West Attica (UniWA), Aigaleo, Greece |
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Citation
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M. Trapali. Oxidic Degradation of Lipids in Patients with Type II Diabetes. Rev. Clin. Pharmacol. Pharmacokinet., Int. Ed. 35(2): 75-77 (2021). DOI:10.5281/zenodo.10030548
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Publication Date
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14-07-2021
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Full Text Language
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Αγγλικά – English |
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Keywords
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Type II Diabetes, lipids, oxidation
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Other Terms
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Μελέτη |
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Summary
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Lipid peroxide-mediated damage has been observed in the development of type 2 diabetes mellitus. The aim of this study was the measurement of oxidic degradation of lipids in diabetic patients. The degree of lipid peroxidation was determined by the reaction of thiobarbituric acid with malondialdehyde, a secondary product of lipid peroxidation. The absorbance of clear supernatant was measured against reference blank at 530 nm. Plasma MDA levels in diabetics were observed to be statistically significantly higher than in control group (p<0.05). | |
| References | 1. Wild, S., Roglic, G., Green, A., Sicree, R., King, H., 2004. A global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 1047–1053. 2. Singh, S., 2011. The genetics of type 2 diabetes mellitus: a review. J. Sci. Res. 55, 35–48. 3. World Health Organization. The top 10 causes of death fact sheet. World Health Organization. http://www.who.int/mediacentre/factsheets/fs310/en/. Updated January 2017. 4. International Diabetes Federation. IDF Diabetes Atlas. Ninth edition 2019. https://www.diabetesatlas.org/upload/resources/2019/IDF_Atlas_9th_Edition_2019.pdf. Accessed: 24 Nov 2019. 5. Baynes J. and Dominiczak, 2014, Medical Biochemistry, Saunders Elsevier 6. Mosely H., Reid R., Yousef S., Boyle S., 2013. A specific, accurate, and sensitive measure of total plasma malondialdehyde by HPLC. J Lipid Res., 54(3), 852–858. 7. Weiss SL, Deutschman CS,2014. Elevated malondialdehyde levels in sepsis – something to ‘stress’ about? Crit Care., 18(2),125. 8. Kuyvenhoven JP, Meinders AE, 1999. Oxidative stress and diabetes mellitus pathogenesis of long-term complications. EJIM, 10, 9-19. |
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Relative Papers
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Online ISSN 1011-6583
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