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Τίτλος – Title
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The role of macrophages in the inflammatory phase during wound healing |
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Συγγραφέας – Author
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Charalambos Charalambous1, Aristidis Vasilopoulos2,3, Zoe Roupa4, Agoritsa Koulouri5 1 BSc, PG Cert WHTR, MPH Deputy Ward Manager, Acute Trauma and Surgical Unit North West of Anglia Foundation Trust, Hinchingbrooke Hospital. United Kingdom 4 MD, RN, PhD Professor, Coordinator of the Nursing Program and Postgraduate pro- gram Contemporary Nursing, University of Nicosia. Cyprus |
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Παραπομπή – Citation
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C. Charalambous, A. Vasilopoulos, Z. Roupa, A. Koulouri. The role of macrophages in the inflammatory phase during wound healing. Review Clin. Pharmacol. Pharmacokinet. 2018, 32, 2, 71-76 |
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Ημερομηνία Δημοσιευσης – Publication Date
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16-07-2018
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Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Αγγλικά – English |
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Λέξεις κλειδιά – Keywords
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Macrophages, wounds, inflammatory phase, wound healing |
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Λοιποί Όροι – Other Terms
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Έρευνα Research |
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Περίληψη – Summary
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Introduction: Macrophage are the predominant cells during the inflammatory phase, it has been demonstrated that wounds cannot heal without the participation of this cells. Anomalies in cellular level can initiate a stagnation state which can lead the wound bed in a destructive inflammatory loop, dysregulating the normal wound healing process. Objective: The main objective was through the review of the scientific literature to establish the role that macrophages have during the inflammatory phase.Methodology: The scientific Greek and English litera- ture was reviewed through Cinahl, Pub-med, EBSCO and Google scholar between September 2016 and October 2016. 5 articles were identified. The articles were chosen due to their direct correlation with the objective under study and their scientific relevance. Result: The absence or reduced numbers of macro- phages from the wound bed leads to inadequate wound debridement and fibrosis, delayed fibroblast prolifera- tion, and collagen deposition. Their abilities to control the microenvironment of the wound during the inflam- matory phase, is attributed to their abilities to create and secrete metalloproteinases during the cleansing phase of the wound healing and additionally the regula- tion of the deposition of new tissue through the secre- tion of growth factors and cytokines. Conclusion: The role and the effect that macrophages have in the process of wound healing have been exten- sively studied. As a result of the progress in under- standing the different cellular functions, the attention has been turned towards the utilization of the multifacto- rial abilities of this cells towards the healing and treat- ment of chronic or stagnated wounds. |
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| Αναφορές – References |
1. Falls. Geneva (Switzerland): World Health Organization; 2012. Available: www.who.int/mediacentre/factsheets/fs344/en/index.html (ac- cessed 2013 Aug. 8). 2. Rubenstein LZ, Josephson KR. Falls and Their Prevention in Elderly People: What Does the Evi- dence Show? Med Clin N Am 2006; 90: 807–824. 4. Stalenhoef PA, Crebolder HFJM, Knottnerus JA, Van Der Horst FGEM. Incidence, risk factors and consequences of falls among elderly subjects living in the community. A criteria-based analysis. European Journal of Public Health 1997; 7: 328-334. 5. Malasana G, Brignole M, Daccarett M, Sher- wood R, Hamdan MH. The Prevalence and Cost of the Faint and Fall problem in the State of Utah. PACE 2011;34:278-283. 6. Tinetti M, Doucette J, Claus E, Marottoli R. Risk factors for serious injury during falls by older per- sons in the community. J Am Geriatr Soc 1995; 43 (11):1214–1221. 7. Vellas BJ, Wayne SH, Romero LJ, Baumgartner RN, Garry PJ. Fear of falling and restric- tion of mobility in elderly fallers. Age Ageing 1997;26 (3): 189–193. 8. Cumming RG, Salked G, Thomas M, Szonyi G. Prospective study of the impact of fear of falling on activities of daily living, SF-36 scores, and nursing home admission. J Gerontol A Biol Sci Med Sci 2000 (5); 55: 299–305. 9. Stevens JA, Corso PS, Finkelstein EA, Miller TR. The costs of fatal and non-fatal falls among older adults. Inj Prev. 2006 (5); 12:290–295. 11. Santos SSC, Silva ME, Pinho LB, Gautério DP, Pelzer MT, Silveira RS. Risk of falls in the elderly: an integrative review based on the North American Nursing Diagnosis Association. Rev Esc Enferm USP 2012; 46 (5):1224-1233. 12. Shanthi GS, Krishnaswamy B. Risk Factors for Falls in Elderly. Journal of the Indian Academy of Geriatrics, 2005; 2: 57-60. 14. Curl A, Thompson CW, Aspinall P, Ormerod M. Developing an audit checklist to assess outdoor falls risk. Proc Inst Civ Eng Urban Des Plan. 2016; 169 (3): 138–153. 15. Muir SW, Berg K, Chesworth B, Klar N, Speechley M. Quantifying the magnitude of risk for balance impairment on falls in community dwelling older adults: a systematic review and meta-analysis. J Clin Epidemiol 2010; 63 (4):389-406. 16. Rubenstein LZ, Josephson KR. The epidemi- ology of falls and syncope. Clin Geriatr Med 2002; 18 (2): 141–158. 18. Biderman A, Cwikel J, Fried AV, Galinsky D. Depression and falls among community dwelling elderly 98 REVIEW OF CLINICAL PHARMACOLOGY AND PHARMACOKINETICS, INTERNATIONAL EDITION 2016 people: a search for common risk factors. J Epidemiol Community Health 2002; 56 (8): 631–636. 20. Woolcott JC, Richardson KJ, Wiens MO, Patel B, Marin J, Khan KM, Marra CA. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med 2009;169 (1): 1952-1960. 21. Hegeman J, van den Bemt BJ, Duysens J, van Limbeek J. NSAIDs and the risk of accidental falls in the elderly: a systematic review. Drug Saf 2009; 32 (6): 489-498. 22. Sterke CS, Verhagen AP, Van Beeck EF, van der Cammen TJ. The influence of drug use on fall inci- dents among nursing home residents: a systematic review. Int Psychogeriatr 2008; 20 (5):890-910. 23. Hartikainen S, Lonnroon E, Louhivuori K. Medication as a risk factor for falls: critical systematic review. J Gerontol 2007; 62 (10): 1172-1181. 25. Wildes TM, Dua P, Fowler SA, Miller J. P, Carpenter CR, Avidan MS, Stark S. Systematic Review of Falls in Older Adults with Cancer. J Geriatr Oncol. 2015; 6 (1): 70–83. 26. Gates S, Smith LA, Fisher JD, Lamb SE. Systematic review of accuracy of screening instruments for predicting fall risk among independently living older adults. J Rehabil Res Dev 2008; 45 (8): 1105-1116. 27. Oliver D, Papaioannou A, Giangregorio L, Thabane L, Reizgys K, Foster G. A systematic review and meta-analysis of studies using the STRATIFY tool for prediction of falls in hospital patients: How well does it work? Age Ageing 2008; 37 (6):621-627. 28. Panel on Falls Prevention. Guideline for the prevention of falls in older persons. American Geriatrics Society, British Geriatrics Society, American Academy of Orthopaedic Surgeons. J Am Geriatr Soc 2001; 49 (5): 664–672. 29. Brian JC, Potter JF. Cardiovascular causes of falls. Age and Ageing 2001; 30:19-24. 31. Koliopoulos Τ, Babatsikou F, Koutis C. De- sign Evaluation of a Communal Care Building Facility for People with Alzheimer’s Disease. International Jour- nal of Caring Sciences 2016; 9 (1): 348-357. 32. Babatsikou F, Koliopoulos T, Koutis Ch. Efficient Design of a Community Health Construction Infrastructure and Public Health Protection in Emergen- cies. Review of Clinical Pharmacology and Pharma- cokinetics, International Edition 2017; 31 (2):79-84. 34. Hoffman Wold G. Basic Geriatric Nursing. Elsevier Company, 5th Edition, 2014. Editing Greek Edition F. Babatsikou. Parisianou S. A., Athens-Greece, 2017. 35. Panel on Prevention of Falls in Older Per- sons. Summary of the Updated American Geriatrics Society/British Geriatrics Society clinical practice guide- line for prevention of falls in older persons. J Am Geriatr Soc. 2011; 59 (1):148–157. 36. Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, Lamb SE. Inter- ventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2012; (9):CD007146. 37. Moyer VA. Prevention of falls in community- dwelling older adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2012; 157 (3):197–204. 38. Stevens JA, Phelan EA. Development of STEADI: a fall prevention resource for health care pro- viders. Health Promot Pract. 2013; 14 (5):706–714. 40. Shaw FE, Bond J, Richardson DA, Dawson P, Steen IN, McKeith IG, Kenny RA. Multifactorial inter- vention after a fall in older people with cognitive im- pairment and dementia presenting to the accident and emergency department: randomized controlled trial. BMJ 2003; 326: 73–78. 41. Lord SR, Castell S, Corcoran J, Dayhew J, Matters B, Shan A, Williams P. The effect of group ex- ercise on physical functioning and falls in frail older people living in retirement villages: a randomized, con- trolled trial. J Am Geriatr Soc 2003; 51 (12): 1685– 1692. 42. Morgan RO, Virnig BA, Duque M, Abdel-Moty E, Devito CA. Low-intensity exercise and reduction of the risk for falls among at-risk elders. J Gerontol: Med Sci 2004; 59 (10): 1062–1067. 43. Suzuki T, Kim H, Yoshida H, Ishizaki T. Ran- domized controlled trial of exercise intervention for the prevention of falls in community-dwelling elderly Japa- nese women. J Bone Miner Metab 2004; 22 (6):602– 611. 44. Helbostad JL, Sletvold O, Nilssen-Moe R. Effects of home exercises and group training on func- tional abilities in home-dwelling older persons with mo- bility and balance problems. A randomized study. Aging Clin Exp Res 2004; 16 (2): 113–21. 45. Thompson A. Homes that Heal and those that don’t. How your home could be harming your family’s health. Editing Greek Edition Ch. Koutis, F. Babatsikou. Parisianou S. A., Athens-Greece, 2015. 46. Nikolaus T, Bach M. Preventing falls in com- munity-dwelling frail older people using a home inter- vention team (HIT): results from the randomized falls- HIT trial. J Am Geriatr Soc 2003; 51 (3): 300–305. 47. Menant JC, Steele JR, Menz HB, Munro BJ, Lord SR. Optimizing footwear for older people at risk of falls. J Rehabil Res Dev 2008; 45 (8):1167-1181. the elderly: a randomized trial. J Am Geriatr Soc 2004;52 (9): 1487–1494. 49. Haines TP, Bennell KL, Osborne RH, Hiil KD. Effectiveness of targeted falls prevention program in subacute hospital setting: randomized controlled trial. BMJ 2004; 328 (7441):676–679. 50. Perell KL, Nelson A, Goldman RL, Luther SL, Prieto-Lewis N, Rubenstein LZ. Fall risk assessment measures: an analytic review. J Gerontol 2001; 56 (12): 761–766. 51. Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, Staehelin HB, Bazemore MG, Zee RY, Wong JB. Effect of vitamin D on falls: a meta-analysis. JAMA 2004; 291 (16): 1999–2006. 52. Gleeson M, Sherrington C, Keay L. Exercise and physical training improve physical function in older adults with visual impairments but their effect on falls is unclear: a systematic review. Journal of Physiotherapy 2014; 60 (3): 130–135. 53. Chang JT, Morton SC, Rubenstein LZ, Mojica WA, Maglione M, Suttorp MJ, Roth EA, Shekelle PG. Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomized clinical trials. BMJ 2004; 328 (7441):680–683. 54. Day L, Fildes B, Gordon I, Fitzharris M, Flamer H, Lord S. Randomized factorial trial of falls prevention among older people living in their own homes. BMJ 2002;325 (7356):128–133. 55. Becker C, Kron M, Lindemann U, Sturm E, Eichner B, Walter-Jung B, Nikolaus T. Effectiveness of a multifaceted intervention on falls in nursing home resident. J Am Geriatr Soc 2003; 51 (3):306–313. 56. Kannus PA. Effectiveness of hip protectors. Effectiveness of studied hip protector was uncertain. BMJ 2003; 326 (7395): 930. 59. Sirkin AJ, Rosner NG. Hypertensive man- agement in the elderly patient at risk for falls. Journal of the American Academy of Nurse Practitioners 2009; 21 (7): 402–408. 60. Foss AJ, Harwood RH, Osborn F, Gregson RM, Zaman A, Masud T. Falls and health status in eld- erly women following second eye cataract surgery: a randomized controlled trial. Age Ageing 2006; 35 (1):66-71. 61. Gates S, Fisher JD, Cooke M, Carter YH, Lamb SE. Multifactorial assessment and targeted inter- vention for preventing falls and injuries among older people in community and emergency care settings: systematic review and meta-analysis. BMJ 2008; 336 (7636):130-133. 62. Day LM. Fall prevention programs for com- munity-dwelling older people should primarily target a multifactorial intervention rather than exercise as a single intervention. J Am Geriatr Soc 2013; 61 (2):284- 285. 63. Luk JK, Chan TY, Chan DK. Falls prevention in the elderly: translating evidence into practice. Hong Kong Med J 2015; 21 (2):165–171. |
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Σχετικές Εργασίες – Relative Papers
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Online ISSN 1011-6583
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Articles published in this Journal are Indexed or Abstracted in:
• Chemical Abstracts
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
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Τι είναι η Review of Clinical Pharmacology and Pharmacokinetics-Διεθνής Έκδοση-Οδηγίες προς τους Συγγραφείς
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