Title | Omega-3 fatty acids from fish and fish oils: nutritional and health effects | |
Author | Artemis P. SimopoulosLecturer of Medicine. President of the Center Genetic, Nutrition and Health, Washington | |
Citation | Simopoulos, A.P.: Omega-3 fatty acids from fish and fish oils: nutritional and health effects, Epitheorese Klin. Farmakol. Farmakokinet. 1(1): 23-32 (1987) | |
Publication Date | 1987-07 | |
Full Text Language | English | |
Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €) pharmakonpress[at]pharmakonpress[.]gr | |
Keywords | Omega-3, ω-3, fatty acids, metabolism, fish, nutrition, health effect. | |
Other Terms | review article | |
Summary | Different studies showed that ω-3 fatty acids, via their conversion to eicosanoids and by interference in prostaglandin metabolism, exert profound effects on several physiological functions. This review presents the actions of ω-3 fatty acids on cardiovascular disease (hypolipidemic, hypotensive and antithrombotic effects), inflammation, immunology and cancer, their role in growth and development and give the sources of these acids and dietary recommendations. | |
References | 1. Tinoco, J.: Dietary requirement and functions of alpha-linolenic acid in animals. Prog. Lipid Res. 21: 1 (1982) 2. Weber, P. et al.: Dietary omega-3 polyunsaturated fatty acids and eicosanoid formation in man. In: (Simopoulos, A.P. et al., eds) Health effects of polyunsaturated fatty acids in seafoods, p. 49, Orlando. F.L., Academic Press, 1986 3. Salem. Jr. N. et al.: Docosahexaenoic acid: Membrane function and metabolism. In: (Simopoulos, A.P. et al., eds), Health Effects of Polyunsaturated Fatty Acids in Seafoods, p. 263, Academic Press, Orlando F.L., 1986 4. Harris, W.S. et al.: Will dietary omega-3 fatty acids change the composition of human milk? Am. J. Clin. Nutr. 40: 780 (1984) 5. Needleman, P. et al.: Trlene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties. Proc. Natl. Acad. Sci. U.S.A., 76: 944 (1979) 6. Lewis, R.A. et al.: Effects of omega-3 fatty acids on the generation of products of the 5-lipoxygenase pathway. In: (Simopoulos, A.P. et al., eds), Health Effects of Polyunsaturated Fatty Acids in Seafoods, p. 227, Academic Press, Orlando, F.L., 1986 7. Keys, A. et al.: ”Essential•’ fatty acids, degree of unsaturation and effect of corn (maize) oil on the serum cholesterol level in man. Lancet i: 66 (1957) 8. Ahrens, E.H. et al.: The effect on human serum lipids of a dietary fat, highly unsaturated, but poor in essential fatty acids. Lancet i: 115 (1959) 9. Pfeifer, J.J. et al.: The lipid depressant activities of whole fish and their component oils. J. Am. OH. Chem. Soc. 39: 292 (1962) 10. Bronte-Stewart, B.A. et al.: Effect of feeding different fats on serum-cholesterol level. Lancet i: 521 (1956) 11. Nelson, A.M.: Diet therapy in coronary disease. Effect on mortality of high-protein, high-seafood, fat-controlled diet. Geriatrics 12: 103 (1972) 12. Nelson, A.M., Douglas, C.: The effect of a fat-corn rolled diet on patients with coronary disease. Med. Welt. 36: 2063 (1965) 13. Kinsell, L.W., Sinclair, H.M.: Letter to the editor. Lancet i: 883 (1957) 14. Stansby, M.E.: Nutritional properties of fish oils. World Rev. Nutr. Diet. 11: 46 (1969) 15. Bang, H.O., Dyerberg, J.: Plasma lipids and lipoproteins in Greenlandic West Coast Eskimos. Acta Med. Scand. 192: 85 (1972) 16. Dyerberg, J. et al.: Fatty acid composition of the plasma lipids in Greenland Eskimos. Am. J. Clin. Nutr. 28: 958 (1975) 17. Bang, H.O. et al.: The composition of food consumed by Greenlandic Eskimos. Acta Med. Scand. 200: 69 (1976) 18. Dyerberg, J. et al.: Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis. Lancet ii: 117 (1978) 19. Dyerberg, J., Bang, H.O.: Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet ii: 433 (1979) 20. Bang, H.O., Dyerberg, J.: Lipid metabolism and ischemic heart disease in Greenland Eskimos. In: (Draper, H.H., ed.). Advanced Nutrition «Research, Vol. 3, p. 1, Plenum Press, New York, 1980 21. Hirai, A. et al.: Eicosapentaenoic acid and platelet function in Japanese. Lancet ii: 1132 (1980) 22. Kromhout, D. et al.: The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N. Engl. J. Med. 312: 1205 (1985) 23. Lee, T.H. et al.: Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N. Engl. J. Med. 312: 1217 (1985) 24. Phillipson, B.E. et al.: Reduction of plasma lipids, lipoproteins and apoproteins by dietary fish oils in patients with hypertriglyceridemia. N. Eng. J. Med. 312: 1210 (1985) 25. Shekelle, R.B. et al.: Letter to the editor. N. Eng. J. Med. 313: 820 (1985) 26. Harris, W.S. et al.: The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: salmon oil versus vegetable oils. Metabolism 32: 179 (1983) 27. Nestel, P.J. et al.: Suppression by diets rich in fish oil of very low density lipoprotein production in man. J. Clin. Invest. 74: 82 (1984) 28. Illingworth, D.R. et al.: Inhibition of low density lipoprotein synthesis by dietary omega-3 fatty acids in humans. Arteriosclerosis 4: 270 (1984) 29. Nestel, P.J.: Fish oil attenuated the cholesterol induced rise in lipoprotein cholesterol. Arri. J. din. Nutr. 43: 752 (1986) 30. Singer, P. et al.: Long-term effect of mackerel diet on blood pressure, serum lipids and thromboxane formation in patients with mild essential hypertension. Atherosclerosis 62: 259 (1986) 31. Goodnight, S.H. et al.: The effects of dietary omega-3 fatty acids on platelet composition and function in man: A prospective, controlled study. Blood 58: 880 (1981) 32. Thorngren, M. et al.: Non-involvement of thromboxane A2 in the delay of primary hemostasis induced by a fish diet. J. Hemat. 58: 567 (1984) 33. Barcelli, U.O. et al.: Effect of increased dietary omega- 3 fatty acids on fibrinolytic activity. Conference on 0mega-3 Fatty Acids. Reading, England. 34. Goodnight, Jr., S.H.: The antithrombotic effects of fish oil. In: (Simopoulos A.P. et al., eds), Health Effects of Polyunsaturated Fatty Acids in Seafoods, p. 135, Academic Press, Orlando, F.L., 1986 35. Saynor, R. et al.: The long-term effect of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina. Atherosclerosis 50: 3 (1984) 36. Landymore, R.W. et al.: Comparison of cod liver oil and aspirin-dypyridamole for the prevention of intimal hyperplasia in autologous vein grafts. Ann. Thoracic Surg. 41: 54 (1986) 37. Weiner, B.H. et al.: Inhibition of atherosclerosis by cod liver oil in a hyperlipidemic swine model. N. Eng. J. Med. 315: 841 (1986) 38. Davis, H.R. et al.: Fish oil prohibits the development of atherosclerosis in rhesus monkeys. Circulation 74: 11 (1986) 39. Simopoulos, A.P. et al., eds: Health Effects of Polyunsaturated Fatty Acids in Seafoods, Academic Press, Orlando, F.L., 1986 40. Prickett, J.D. et al.: Dietary enrichment with the polyunsaturated fatty acid eicosapentaenoic acid prevents proteinuria and prolongs survival in NZB * NZW/F, mice. J. Clin. Invest. 68: 556 (1981) 41. Goetzel, E.J. et al.: Effects of eicosapentaenoic acid on immune responses and inflammation in humans. In: (Simopoulos A.P. et al., eds’), Health Effects of Polyunsaturated Fatty Acids in Seafoods, p. 239, Academic Press, Orlando, FL, 1986 42. Kremer, J.M. et al.: Fish-oil fatty acid supplementation in active rheumatoid arthritis. Ann. Intern. Med. 106: 497 (1987) 43. Kamada, T. et al.: Dietary sardine oil increases erythrocyte membrane fluidity in diabetic patients. Diabetes 35: 604 (1986) 44. Karmali, R.A. et al.: Effect of omega-3 fatty acids on growth of a rat mammary tumor. J. Nat. Cancer Inst. 73: 457 (1984) 45. Turkowski, J.J., Cave, W.T.: Dietary effects of menhaden oil on rat mammary tumors. J. Nat. Cancer Inst. 74: 1145 (1985) 46. Walker, B.L.: Maternal diet and brain fatty acids in young rats. Lipids 2: 497 (1967) 47. Benolken, R.M. et al.: Membrane fatty acids associated with the electrical response in visual excitation. Science 182: 1253 (1973) 48. Lamptey, M.S., Walker, B.L.: A possible essential role of dietary linolenic acid in the development of the young rat. J. Nutr. 106: 86 (1976) 49. Neuringer, M. et al.: Dietary ofnega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. J. Clin. Invest. 73: 272 (1984) 50. Holman, R.T.: Essential fatty acid deficiency. Prog. Chem. Fats Lipids 9: 275 (1970) 51. Bjerve, K.S. et al.: Alpha-linolenic acid deficiency in patients on long-term gastric-tube feeding: estimation of linolenic acid and long-chain unsaturated n-3 fatty acid requirement in man. Am. J. Clin, Nutr. 45: 66 (1987) 52. Bradlow, B.A.: Thrombosis and omega-3 fatty acids: epidemiological and clinical aspects. In: (Simopoulos, A.P. et al., eds). Health Effects of Polyunsaturated Fatty Acids in Seafoods, p. 111, Academic Press, Orlando, FL, 1986 53. Rice, D.R.: The effects of low doses of Max EPA for long periods. Br. J. Clin. Pract. 81 (Suppl.J: 78 (1983) 54. Mostensen, J.Z. et al.: The effects of omega-6 and omega-3 polyunsaturated fatty acids on hemostasis blood lipids and blood pressure. Thromb. Haemost. 50: 543 (1983) 55. Leaf, A. et al.: A new ear for science in nutrition. Am. J. Clin. Nutr. 45 (Suppl. J, (1987) 56. de Gomez Dumm, I.N.T., Brenner, R.R.: Oxidative desaturation of alpha-linolenic, linoleic and stearic acids by human liver microsomes. Lipids 10: 315 (1975) 57. Hague, T.A., Christoffersen, B.O.: Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to CM fatty acids in isolated liver cells. Biochim. Biophys. Acta 796: 205 (1984) |
|
Relative Papers |
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1987 – ANNUAL SUBSCRIPTION 1987 | |
Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)pharmakonpress[at]pharmakonpress[.]gr |
Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)pharmakonpress[at]pharmakonpress[.]gr |