Title | Retinoblastoma: a prototype childhood malignancy | |
Author | Vasiliki A. Malliopoulou
Department of Biological Chemistry, University of Athens Medical School, Athens |
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Citation | Malliopoulou, V.: Retinoblastoma: a prototype childhood malignancy, Epitheorese Klin. Farmakol. Farmakokinet. 2(2): 85-90 (1988) | |
Publication Date | 1988-10 | |
Full Text Language | English | |
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Keywords | Retinoblastoma, cancer, gene, Rb gene, chromosomal abnormalies, phosphoprotein, DNA. | |
Other Terms | review article | |
Summary | The retinoblastoma gene belongs to a class of recessive human cancer genes that have a “suppressor” or “regulatory” function. The mechanism in the development of retinoblastoma, which requires loss or inactivation of both copies of the normal Rb gene, is in direct contrast to that of putative human oncogenes, which are thought to induce tumor/genesis following activation or alteration. The development of osteosarcoma in patients carrying a retinoblastoma predisposing allele suggests that this allele plays a role in the etiology of both tumors. The finding of chromosomal abnormalities in a significant fraction of reginoblastoma raises the possibility that such abnormalities may also play primary roles in retinoblast transformation. Finally, the protein of retinoblastoma gene is a phosphoprotein with DNA- binding activity, but unknown function. | |
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