| Title | Action de la cinnarizine sur l ‘aorte du rat: sôn role dans la mobilisation du calcium au niveau cellulaire | |
| Authors | M. Kotoula, V. Kokkas, C. Papadopoulos et A. Paradelis
Laboratoire de Pharmacologie Experimentale, Faculty de Medecine, Universite Aristote de Thessalonique, Grece |
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| Citation | Kotoula, M., Kokkas, V., Papadopoulos, C., Paradelis, A.: Action de la cinnarizine sur l ‘aorte du rat: sôn role dans la mobilisation du calcium au niveau cellulaire, Epitheorese Klin. Farmakol. Farmakokinet. 2(2): 103-109 (1988) | |
| Publication Date | 1988-10 | |
| Full Text Language | French | |
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| Keywords | Cinnarizine, aorte, calcium, cellulaire, KCI, mobilisation. | |
| Other Terms | review article | |
| Summary | L‘action de la cinnarizine sur l’aorte du rat et son role dans la mobilisation du calcium au nivau cellulaire ont ete examines, le verapamil et la cinnarizine, utilises a la meme concentration (100 μΜ), ont presque la meme action dilatatrice sur l’ aorte deja contractee par le chrorure de potassium (KCl). On connait que le KCI empeche I ‘entree du calcium extracellulaire dans la cellule. Au contraire, la cinnarizine a montre une action inhibitrice sur l’ action contracturante de la noradrenaline (phase phasique) plus forte que celle produite par le verapamil. Il est bien connu que la noradrenaline contracte le muscle lisse en stimulant l’ entree du calcium extracellulaire et en meme temps en mobilisant le calcium intracellulaire. Donc, les resultats cidessus permettent de suggerer que la cinnarizine n ‘est pas seulement un inhibiteur de I ‘entree du calcium extracellulaire, mais il peut en meme temps empecher la mobilisation du calcium intracellulaire. | |
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Online ISSN 1011-6575
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