Τόμος 4 (1990) – Τεύχος 1 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 4 (1990) – Issue 1 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Endothelium functions an update consideration
Authors Stavros T. Plessas¹, Charalambos T. Plessas¹ and Alfred de Courten²

1. PHARMAKON-Press Information Services, Athens, Greece

2. OM Laboratories, Geneva, Switzerland

Citation Plessas, S.T., Plessas, C.T., de Courten, A.: Endothelium functions an update consideration, Epitheorese Klin. Farmakol. Farmakokinet. 4(1): 3-11 (1990)
Publication Date Received for publication: September 1, 1989

Accepted for publication: January 15, 1990

Full Text Language English
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Keywords Endothelium, prostacyclin, endothelium-derived relaxing factor, endothelium-derived hyperpolarizing factor, endothelin, antithrombogenic properties.
Other Terms review article
Summary The endothelium of blood vessels plays a diffusional barrier role, contributes to the vasomotor tone of the vessel and exhibits antithrombogenic properties. These functions are achieved with the secretion, from the endothelial cells, of vasoactive substances, (a) vasodilators, including the prostacyclin, the endothelium-derived relaxing factor (newly identified as nitric oxide), both of which have antithrombogenic properties as well, and the endothelium-derived hyperpofarising factor, and (b) vasoconstrictors, including the newly discovered endothelin. Under normal states the effects of vasodilating substances are predominant, whereas in pathological conditions, such as hypertension and atherosclerosis, those of vasoconstricting substances are increased. The functional changes of the endothelium occurring in cardiovascular diseases could facilitate the understanding of the mechanism of a large artery vasospasm, thrombosis and hypertension and the mode of action of certain vasodilator drugs.
References 1.         Steinberg. N.: The cholesterol controversy is over. Why dit it take so long? Circulation 80: 1070 (1989)

2.         Ritter, J.M., Blair, J.A., Barrow, S.E., Dollery, C.T.: Release of prostacyclin in vivo and its role in man. Lancet I: 317 (1983)

2a.       Plessas, C.T., Plessas, S.T.: Antiplatelet drugs: clinical pharmacology and pharmacokinetics. Epitheor. Klin. Farmakol. FarmakokineL, Int. Ed., 1: 5 (1987)

3.         Angus, J.A., Cocks, T.M.: Endothelial cell function and blood vessel reactivity. Med. Progr. No. 7: 23 (1989)

4.         Oates, J.A., Falardeau, P., Fitzgerald, G., Branch, R.A., Brash, A.R.: Quantification of urinary prostacyclin metabolites in man: estimates on the rate of secretion of prostacyclin into the general circulation. In: Clinical Pharmacology of Prostacyclin (P.J. Lewis, J. O’Grady, eds), p. 21, Raven Press, New York, 1981

5.         Fitzgerald, G.A., Friedman, LA., Miyamori, J., O’Grady, J., Lewis, P.J.: A double blind placebo controlled crossover study of prostacyclin in man. Life Sci. 25: 665 (1979)

6.         Siegl, A.M., Smith, J.B., Silver, M.J., Nicolaou, K.C., Ahern, D.: Selective binding site for [3H] prostacyclin on platelets. J. Clin. Invest. 63: 215 (1979)

7.         MacDermot, J., Barnes, P.J., Waddell, K.A., Dollery, C.T. Blair, J.A.: Prostacyclin binding to guinea-pig pulmonary receptors. Eur. J. Pharmacol. 75: 127 (1981)

8.         Masotti. G., Poggesi, L., Galanti, G., Trotta, F., Neri-Serneri, G.G. Prostacyclin production in man. In: Clinical Pharmacology of Prostacyclin (P.J. Lewis, J. 0’Grady, eds), p. 9, Raven Press, New York, 1981

9.         Nizankowski, R. et al.: Prostacyclin for ischaemic ulcers in peripheral arterial disease. A random assignment, placebo controlled study. Thromboxane Research 37: 21 (1985)

10.       Belch, J.J.F. et al.: Intermittent epoprostenol (prostacyclin) infusion in patients with Raynaud’s syndrome. Lancet 1: 313 (1983)

11.       Huczynski, J. et al.: Double-blind controlled trial of the therapeutic effects of prostacyclin in patients with completed ischaemic stroke. Stroke 16: 810 (1985)

12.       Henriksson, P. et al.: Prostacyclin infusion in patients with acute myocardial infarction. Brit. H. J. 53: 173 (1985)

13.       Barts, R.J.: Pharmacologically induced pulmonary vasodilatation in children and young adults with primary pulmonary hypertension. Chest 89: 497 (1986)

14.       Furchgott, R.F. and Zawadski, J.V.: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373 (1980)

15.       Furchgott, R.F.: Role of endothelium in responses of vascular smooth muscle to drugs. Ann. Rev. Pharmac. Tox. 24: 175 (1984)

16.       Radomski, Palmer, R.M.J., Moncada, S.: The anti- aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br. J. Pharmac. 92: 639 (1987)

17.       Palmer, R.M.J., Ferrige, A.G., Moncada, S.: Release of nitric oxide accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524 (1987)

18.       Feigl, E.O.: Endothelium-derived relaxing factor may be a protective factor. Nature 331: 490 (1988)

19.       Rubanyi, G.M., Vanhoutte, P.M.: Superoxide anions and. hyperoxia inactivate endothelium-derived relaxing factor. Am. J. Physiol. 250: H822 (1986)

20.       Forstermann, U., Miigge, A., Bode, S.M., Frolich, J.C.: Response of human coronary arteries to aggregating platelets: Importance of endothelium-derived relaxing factor and prostanoids. Circ. Res. 63: 306 (1988)

21.       Furlong, B., Hendersdn, A.H., Lewis, M.J., Smith, J.A.: Endothelium-derived relaxing factor inhibits in vitro platelet aggregation. Br. J. Pharmac. 90: 687 (1987)

22.       Azuma, H„ Ishikawa, M., Sekizaki, S.: Endothelium-dependent inhibition of platelet aggregation. Br. J. Pharmac. 88: 411 (1986)

23.       Martin, W., Villani, G.M., Jothianandan, D., Furchgott. R.F.: Blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation of rabbit aorta by certain ferrous haemoproteins. J Pharmac. Exp. Ther. 233: 679 (1985)

24.       Gryglewski, R.J., Palmer, R.M.J., Moncada, S.: Superoxide anion plays a role in the breakdown of endothelium-derived vascular relaxing factor. Nature 320: 454 (1986)

25.       Luscher, T.F., Richard, V.: Role protecteur de I ‘endothelium dans la circulation. Med. et Hyg. 48: 161 (1990)

26.       Yanagisawa, M. et al.: A novel potent vasosconstrictor peptide produced by vascular endothelial cells. Nature 332: 411 (1988)

27.       Luscher, T.F., Diederich, D. et al.: Difference between endothelium-dependent relaxation in arterial and venous coronary bypass grafts. N. Engl. J. Med. 319: 462 (1988)

28.       T.F. Luscher (ed.): Endothelial Vasoactive Substances and Cardiovascular Disease, p. 1, Karger Publ., Basel, Switzerland, 1988

29.       Moncada, S.: Biological importance of prostacyclin. Br. J. Pharmac. 76: 3 (1982)

30.       Zhihong, Y. et al.: Endothelium-derived relaxing factor and protection against contractions, induced by histamine and serotonin in the human internal mammary artery and in the saphenous vein. Circulation 80: 1041 (1989)

31.       Papadoppulos, Κ.: Vasomotor actions on the coronary arteries. Epitheor. Klin. Farmakol. FarmakokineL. Int. Ed. 3: 3 (1989)

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