| Title | Haemodynamic changes induced by streptokinase infusion | |
| Authors | J. Kanonidis, C.L. Papadopoulos, K. Gitsios and G. Sakadamis
2nd Department of Cardiology, Aristotle’s University of Thessaloniki |
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| Citation | Kanonidis, J., Papadopoulos, C.L., Gitsios, K., Sakadamis, G.: Haemodynamic changes induced by streptokinase infusion, Epitheorese Klin. Farmakol. Farmakokinet. 6(2): 99-104 (1992) | |
| Publication Date | Received for publication: 25 April 1992
Accepted for publication: 5 May 1992 |
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| Full Text Language | English | |
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| Keywords | Streptokinase infusion, haemodynamic changes. | |
| Other Terms | review article | |
| Summary | The haemodynamic changes induced by Streptokinase (SK) infusion in patients with Acute Myocardial Infarction (AMI) and normal haemodynamic state were studied in 58 patients (pts). A drop in arterial pressure affecting both the systolic and diastolic blood pressure was noticed in the 53 of the 58 pts (93%). Systolic Blood Pressure (SBP) fell from 142 mmHg to 95 mmHg and Diastolic Blood Pressure (DBP) from 85 mmHg to 65 mmHg. A concomitant drop in the Pulmonary Wedge Pressure (PWP) was recorded in the subgroup of catheterised patients, which dropped from 14.1 mmHg to 8 mmHg. The haemodynamic changes were more prominent in patients with inferior infarction compared to patients with anterior infarction. The event was transient lasting less than 45 mins in all but 4 cases. Nitroglycerine infusion was interrupted in 29 cases and saline infusion was used in 29 pts. The event was considered severe in 15 cases (25.7%), in 4 of which inotropic drugs (dopamine) were used. In all patients normal haemodynamic state was reestablished and no major complications, attributable to the hypotensive effect of the drug, were noticed. | |
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2. Lew, A.S., Laramee, P., Cercek, B., Shah, P.K., Ganz, W.: The hypotensive effect of intravenous streptokinase in patients with acute myocardial infarction. Circulation 72: 1321-1326(1985) 3. Ganz, W., Geft, I., Shah, P.K., Lew, A.S., Rodriguez, L., Weiss, T., Maddahi, J., Berman, D.S., Charuzi, Y., Swan, H.J.C.: Intravenous streptokinase in evolving acute myocardial infarction. Am. J. Cardiol. 53: 1209-1216 (1984) 4. Valentine, R.P., Pitts, D.E., Brooks-Brunn, J.A., Williams, J.G., van Hone, E., Schmidt, P.E.: Intravenous versus intracoronary streptokinase in acute myocardial infarction. Am. J. Cardiol. 55: 309-312 (1985) 5. White, H.D., Norris, R.M., Brown, M.A., Takayama, M., Maslowski, A., Bass, N.M., Ormiston, J.A., Whitlock, T.: Effect of intravenous streptokinase on left ventricular function an early survival after acute myocardial infarction. N. Engl. J. Med. 317: 850-855 (1987) 6. Surnmaria, L., Arzadon, L., Bernabe, P., Robbins, K.C.: The interaction of streptokinase with human, cat, dog and rabbit plasminogens. J. Biol. Chem. 249: 4760-4765 (1974) 7. Anderson, R.G.G., Saldeen, Κ., Saldeen, T.: A fibrin(ogen) derived pentapeptide induces vasodilation, prostacyclin release and an increase in cyclic AMP. Thromb. Res. 30: 213-216 (1983) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1992 – ANNUAL SUBSCRIPTION 1992 | |
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