| Title | The contribution of the atrial natriuretic peptide in arterial pressure regulation | |
| Author | Constantine L. Papadopoulos
2nd Department of Cardiology, Aristotle’s University, Thessaloniki, Greece |
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| Citation | Papadopoulos, C.L.: The contribution of the atrial natriuretic peptide in arterial pressure regulation, Epitheorese Klin. Farmakol. Farmakokinet. 6(3): 117-123 (1992) | |
| Publication Date | Received for publication: 6 November 1992
Accepted for publication: 6 November 1992 |
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| Full Text Language | English | |
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| Keywords | Atrial natriuretic peptide, arterial pressure regulation. | |
| Other Terms | review article | |
| Summary | Mean arterial blood pressure increase is attributed to short term (haemodynamic) or to long-term (renal) changes; the therapeutical means are directed respectively. It is difficult to explain the longterm antihypertensive effect of beta-adrenergic blockers. Recently, it is partially associated to the increased secretion of atrial natriuretic peptide, ANP. Research work of the author and his collaborators has been under taken in this field. Our study was divided into two parts. In the first one the long term and in the second the short term effect of beta-adrenergic blockade were studied on the ANP. The high β1-selective agent bisoprolol was used. Patients with essential hypertension were only included. In the 1st part, plasma ANP changes were studied in correlation to the blood pressure and to the echo- cardiographic dimensions of the left heart cavities in lying position. Plasma ANP levels were raised by 20%, despite the drop of blood pressure and the very small but statistically significant, decrease in left atrial and ventricular diameters. In the 2nd part the effect of posture was studied. Plasma ANP levels in standing position were lower than in lying one, but in both positions they were slightly higher after beta-blockers. The above findings, taken into consideration with the literature data, favour the theory that the antihypertensive action of beta adrenergic blockers is partially due to the increased secretion of ANP. | |
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