Title | Isothiazolinone biocides as preservatives in cosmetics | |
Authors | Athanasia Varvaresou, Efthimios Tsirivas and Eleana Tsaoula
Department of Aesthetics and Cosmetology, The School of Health and Caring Professions, Technological Educational Institution, Ag. Spyridonos Str., GR-12210, Egaleo, Athens, Greece |
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Citation | Varvaresou, A., Tsirivas, E., Tsaoula, E.: Isothiazolinone biocides as preservatives in cosmetics, Epitheorese Klin. Farmakol. Farmakokinet. 19(2): 105-108 (2005) | |
Publication Date | Received for publication: : 17 March 2005
Accepted for publication: 12 May 2005 |
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Full Text Language | English | |
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Keywords | Isothiazolinone biocides, cosmetics, preservatives. | |
Other Terms | review article | |
Summary | This study briefly reviews the published literature regarding the efficacy of isothiazolinone derivatives as preservatives in cosmetic preparations with regard to their influence on the formula stability. The dermatological problems caused by the isothiazolinones are examined and some structure-activity relationships concerning their allergic reactivity are also described. | |
References | 1. Rossmore H.W.: Heterocyclic compounds as industrial biocides. Dev. Ind. Microbiol. 20: 41-71 (1979)
2. a) Tsotinis A., Varvaresou A., Calogeropoulou T., Siatra-Papastaikoudi T., Tyligada E.: Synthesis and Antimicrobial Evaluation of Indole containing Derivatives of 1,3,4- Thiadiazole, 1,2,4-Triazole and their open-chain counterparts Arzneim.-Forsch./Drug Res. 47: 307-310 (1997) b) Varvaresou A., Siatra-Papastaikoudi Th., Tsantili-Kakoulidou A., Tyligada E.: Synthesis and Biological Evaluation of Indole containing Derivatives of Thiosemicarbazides and their Cyclic 1,2,4-Triazole and 1,3,4-Thiadiazole Analogs Arzneim.-Forsch./Drug Res. 50: 48-54 (2000) 3. Reisdorff J.H., Brandes W., Scheinpflug H., Ger. Often. 2, 533 604, 10 Feb 1977 4. Collier P.J., Ramsey R.D., Watgh R.D., Douglas K.T., Austin P., Gilbert P.: Chemical reactivity of some isothiazolone biocides J. Appl. Bacteriol. 69: 578-584 (1990) 5. Collier P.J., Ramsey R.D., Waigh R.D., Douglas K.T., Austin P., Gilbert P.: Growth inhibitory and biocidal activity of some isothiazolone biocides J. Appl. Bacteriol. 69: 569-577 (1990) 6. De Groot A.C., Weyland J.W.: Kathon CG. A review J Am. Acad. Dermatol. 18: 350-358 (1988) 7. Rohm and Haas Technical Bulletin: Kathon CG microbiocide in cosmetics and toiletries. 8. Fewings J., Menne T.A.: An update of the risk assessment for methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) with focus on rinse-off products Contact Dermatitis 41: 1-13 (1999) 9. Basketter D.A., Rodgord R., Kimber I., Smith I., Wahlberg J.E.: Skin sensitization risk assessment: a comparative evaluation of 3-isothiazoIinone biocides Contact Dermatitis 40: 150-154 (1999) 10. Sassevllie D.: Hypersensitivity to preservatives Dermatol. Therapy 17: 251-263 (2004) 11. Morren M.A, Dooms-Goosens A., Delabie J., De Wolf Peeters C., Marien K., Degreef H.: Contact allergy to isothiazolinone derivatives: Unusual clinical presentations Dermatology 184: 260-264 (1992) 12. Bruze M., Fregert S., Gruvberger B., Persson K.: Contact allergy to the active ingredients of Kathon CG in the guinea pig Acta Derm. Venereol. 67: 315-320 (1987) 13. Bruze M., Gruvberger B., Persson K.: Contact allergy to a contaminant in Kathon CG in guinea pigs Dermatosen Beruf Umvelt 35: 165-168 (1987) 14. Lepoittevin J.P., Basketter D.A., Goosens A., Karlberg A.T.: Allergic Contact Dermatitis: The molecular Basis, Springer, Berlin, 1997 15. Sanscez R.A., Basketter D., Pease C., Lepoittevin J.P.: Studies of chemical selectivity of hapten, reactivity and skin sensitization potency 3. Synthesis and Studies on the reactivity toward model nucleophiles of the 13C-labeled skin sensitizers, 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) Chem. Res. Toxicol. 16: 627-636 (2003) 16. Estrada E., Patlewicz G., Gutierrez Y.: From knowledge generation to knowledge archive. A general strategy using TOPS-MODE with DEREK to formulate new alerts for skin sensitization J. Chem. Inf. Comput. Sci. 44: 688-698 (2004) 17. Diehl M.A., Schultz C.M., Shaw D.A., Williams T.M.: A new isothiazolinone preservative for the cosmetics and toiletry industry Cosmetics and Toiletries Manufacture Worldwide Edition Articles (2001) |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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