Τόμος 19 (2005) – Τεύχος 3 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 19 (2005) – Issue 3 – Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

 

Title The influence of magnesium ascorbyl phosphate on moisturization of stratum corneum
Authors  A. Varvaresou, E. Tsirivas, E. Tsaoula and E. Protopapa

Department of Aesthetics and Cosmetology, The School of Health & Caring Professions, Technological Education Institution, Ag. Spyridonos Str., GR-12210-Egaleo, Athens, Greece

Citation Varvaresou, A., Tsirivas, E., Tsaoula, E., Protopapa, E.: The influence of magnesium ascorbyl phosphate on moisturization of stratum corneum, Epitheorese Klin. Farmakol. Farmakokinet. 19(3): 139-142 (2005)
Publication Date Accepted for publication: 5 November 2005
Full Text Language English
Order – Buy  Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €) 

pharmakonpress[at]pharmakonpress[.]gr

Keywords Magnesium ascorbyl phospate, moisturization of stratum corneum, corneometer.
Other Terms review article 
Summary The antioxidant activity of L-ascorbic acid is well established. Topical application of vitamin C has been shown to provide photoprotection, to decrease radiation damage and to prevent UV immunosuppression. L-ascorbic acid was found to stimulate collagen synthesis in monolayer fibroblast cultures and to enhance the hydration of the stratum corneum, as well. The magnesium salt of ascorbyl-2-phosphate (MAP) is a stable derivative of ascorbic acid, which was found to be equivalent to ascorbic acid in stimulating collagen synthesis in monolayer fibroblast cultures. Furthermore, the epidermal transportation and conversion of MAP to L-ascorbic acid has been proved in humans, as well. Although several studies strongly support the idea that ascorbic acid enhances the hydration of stratum corneum, the hydrating properties of MAP have not been examined yet. In this study, tests were carried out in a half face, double blind manner consisting of 28 days usage (twice daily applications). According to our findings the presence of MAP compared to placebo, caused low improvement in the hydration of the skin or the concentration of moisturizing raw materials in the placebo masked its moisturizing property.
References 1.    Colven R.M., Pinell S.R.: Topical Vitamin C in ageing. Clin. Dermatol. 14: 227-234 (1996)

2.    Halperin E.C., Gaspar L., George S., et al.: A double blind randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. Int. Radiat. Oncol. Biol. Phys. 26: 413-16 (1993)

3.    Nakamura T., Pinnell S.R., Darr D., Kurimoto I., et al. : Vitamin C. Abrogates, the Deleterious effects of UV B radiation on cutaneous immunity by a mechanism that does not depend on TNF-a. J. Invest. Dermatol. 109: 20- 24(1997).

4.    Phillips C.L., Combs S.B., Pinell S. R.: Effects of ascorbic acid on proliferation and collagen synthesis in relation to the donor age of human fibroblasts. J. Invest. Dermatol. 130: 228-232 (1994)

5.    Golden G.M., Guzek D.B., Kennedy A.H., Mckie J.E., Potts R.O.: Stratum corneum lipid phase transitions and water barrier properties. Biochemistry 25: 2382-2388 (1986)

6.    Lee A.C., Tojo K.: Characterization of skin permeation of vitamin C: Theoretical analysis of penetration profiles and differential scanning calorimetry study. Chem. Pharm. Bull. 46: 174-177 (1998)

7.    Geesin J.C., Gordon J.S., Berg R.A.: Regulation of collagen synthesis in human dermal fibroblasts by the sodium and magnesium salts of ascorbyl-2-phosphate. Skin Pharmacol 6: 65-71 (1993)

8.    Kameyama K., Sakai C., Kondoh S., et al.: Inhibitory effect of magnesium L-ascorbyl phosphate on melanogenesis in vitro and in vivo. J. Am. Acad. Dermatol. 34: 29-33 (1996)

9.    Varvaresou A., Iakovou K., Filippatos E., Souli C., Calogeropoulou T., Ioannidou I., Kourounakis A., Pannecouque C., Witvrouw M., Padalko E., Neyts J., De Clercq E., Tsotinis A.: Synthesis, Antiretroviral and Antioxidant Evaluation of a Series of new Benzo[b]furan Derivatives. Arzneim. Forsch./Drug Res. 51: 156-162 (2001)

10.  Iakovou K., Varvaresou A., Kourounakis A. P., Stead K., Sugden D., Tsotinis A.: Design, synthesis and biological evaluation of novel conformationally restrained melatoninergic analogs. J. Pharm. Pharmacol. 54: 147-156 {2002)

11.  Ιakovou K., Varvaresou A., Bruni G., Massarelli P., Vavayannis A., Kazanis M.: Anti-inflammatory and Analgesic Activity οf two dicyclic analogues of Acetaminophen and its regioisomer 3-Hydroxyacetanilide Pharm. Chem. J. 38: 239-242 (2004)

12.  Varvaresou A., Tsaoula E., Tsirivas E.: The influence of the addition of melatonin to a magnesium ascorbyl phosphate-containing formulation on the mechanical properties of human skin Rev. Clin. Pharmacol. Pharmacocinet. 18: 177-181 (2004)

13.  Varvaresou A., Tsirivas E., Tsaoula E., Protopapa E.: Oxidative Stress, Photoaging and Topical antioxidant Protection. Rev. Clin. Pharmacol. Pharmacokinet. 18: 261- 266 (2004)

14.  Gloor M., Fluhr I., Lehmann W., Gehring W., Thieroff-Ekerdt R.: Do urea/ammonium lactate combinations achieve better skin protection and hydration than either component alone? Skin. Pharmacol. Appl. Skin. Physiol. 15: 35-43 (2002)

15.  Serup J., Winther A., Blichman W.: Effect of repeated application of a moisturizer. Acta Dermatol. Venereol. 69: 457-459 (1989)

16.  Hashimoto-Kumasaka K., Takahashi K., Tagami H.: Electrical measurement of the water content of the stratum corneum in vivo and in vitro under various conditions: Comparison between skin surface hygrometer and corneometer in evaluation of the skin surface hydration state. Acta Dermatol. Venereol. 73: 335-339 (1993)

17.  Gomes L., Langer C.M., Oliveira E. C., Vairoletto L.: Differentes tipos de pele: Differentes necessidades cosmeticas. Congresso National de Cosmetologia 12, Sao Paolo, 1998 in Anais 1998 pp. 220-231

Relative Papers

Online ISSN 1011-6575

Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:

Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor

Τι είναι η Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση-Οδηγίες προς τους Συγγραφείς – 
What is Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition-Instrunctions to Authors

Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – 
Articles Published in Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Συντακτικη Επιτροπή-Editorial Board

ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2005– ANNUAL SUBSCRIPTION 2005
Γλώσσα Πλήρους Κειμένου – Full Text Language Αγγλικά – English
Παραγγελία – Αγορά – Order – Buy Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)

pharmakonpress[at]pharmakonpress[.]gr

Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)

pharmakonpress[at]pharmakonpress[.]gr

 

 

 

 

 

Bookmark the permalink.

Comments are closed.