| Title | Further studies on the activity of 3β hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam esters of cinnamic acid and mustard isomers in P388 leukemia: a short communication | |
| Authors | Demetrios Catsoulacos and Panayotis Catsoulacos
Laboratory of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece |
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| Citation | Catsoulacos D., Catsoulacos, P.: Further studies on the activity of 3β hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam esters of cinnamic acid and mustard isomers in P388 leukemia: a short communication, Epitheorese Klin. Farmakol. Farmakokinet. 9(1): 39-40 (1995) | |
| Publication Date | Accepted for publication: 30 March 1995 | |
| Full Text Language | English | |
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| Keywords | Antitumor activity of an homo-aza-steroidal esters of cinnamic acid mustard isomers | |
| Other Terms | review article | |
| Summary | As biological platforms for the nitrogen mustard of cinnamic acid isomers has been used 3β-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam. The three esters were tested against P388 leukemia and the ortho substituted was active. | |
| References | 1. Wall, M.E., Abernethy, G.S., Carol, F.I., Taylor, J.: The effect of steroidal alkylating agents on experimental animal mammary tumor and leukemia system. J. Med. Chem. 12 810-818 (1969)
2. Wampler, G.L., Catsoulacos, P.: Antileukemic effect of homo-aza-steroidal ester of p-bis-(2-chlo roethyl)aminophenylacetic acid. Cancer Chemoth. Rep. 61: 37-41 (1977) 3. Catsoulacos, P., Politis, D., Wampler, G.L..: Anti-tumor activity of homo-aza-steroidal esters of p- bis(chloroethyl)aminophenylbutyric acid. Cancer Chemoth. Pharmacol. 10: 129-132 (1983) 4. Catsoulacos, P., Camoutsis, Ch., Wampler, G.L.: Effect of A5-homo-aza-steroidal ester in P388 and L1210 murine leukemias. Oncology 39: 59-60 (1982) 5. Catsoulacos, P., Politis, D., Wampler, G.L.: A new steroidal alkylating agent with improved activity in advanced murine leykemias. Cancer Chemoth. Pharmacol. 3: 67070 (1979) 6. Catsoulacos, P., Wampler, G.L.: Activity of 3β– hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic- 13,17-lactam-p-bis(2-chloroethyl)aminophenylacetate (NCS 290205) in murine solid tumors. Oncology 39: 109-112 (1982) 7. Catsoulacos, P.: Activity of 3β-hydroxy-13α– amino-13,17-seco-5α-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminophenylacetate (NCS 290205) on experimental animal tumor and leukemia systems. Oncology 40: 290-292 (1983) 8. Catsoulacos, P.: Further studies on the antineoplastic activity of 3β-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminophenylacetate (NCS 290205) in murine solid tumors. Cancer Lett 22: 199-202 (1984) 9. Catsoulacos, P., Camoutsis, Ch., Pelekanou, M.: Antileukemic activity of homo-aza-steroidal esters of the isomers of N,N-bis(2-chloroethyl)aminocinnamic acid. Eur. J. Med. Chem. 26: 659-661 (1991) 10. Catsoulacos, P., Camoutsis, Ch., Papageorgiou, A., Margariti, E., Psaraki, K., Demopoulos, E.: Struc- ture-anticancer and structure-genetic activity relationships of homo-aza-steroidal esters of N,N-bis(2- chloroethyl)aminocinnamic acid isomers. J. Pharm. Sci. 82: 204-208 (1993) 11. Anastasiou, A., Catsoulacos, P., Papageorgiou, A., Margariti, E.: On the formation of homo-aza-steroidal esters of N,N-bis-(2-chloroethyl)-aminobenzoic acid isomers and their antitumor activity. J. Heterocyclic Chem. 31: 367-374 (1994) |
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Online ISSN 1011-6575
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