| Title | Designing peptide mimetics | |
| Author | Graham J. Moore1 and John M. Matsoukas2
1. Department of Pharmacology and Therapeutics, The University of Calgary, Faculty of Medicine, 3330 Hospital Drive N. W Alberta T2N 4NI Canada 2. Department of Chemistry, University of Patras, 261 00 Patras, Greece |
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| Citation | Moore, G.J., Matsoukas J.M.: Designing peptide mimetics, Epitheorese Klin. Farmakol. Farmakokinet. 9(2-3): 53-58 (1995) | |
| Publication Date | 1995 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | 2D-NMR spectroscopy, conformational analysis, molecular modelling, peptidomimetic analogs | |
| Other Terms | review article | |
| Summary | Two dimensional Nuclear Magnetic Resonance techniques, such as Correlated Spectroscopy (COSY), Nuclear Overhauser Effect Spectroscopy in the Rotating Frame (ROESY) and one dimensional Nuclear Overhauser Effect Enhancement Spectroscopy (1D-NOE), have proved to be very useful techniques for identifying the conformational features of peptide hormones. Application of these techniques in receptor simulating environments has enabled us to investigate the conformational properties of peptide hormones such as Angiotensin II (ANGII), Gonadotropin-Releasing Hormone (GnRH) and Thrombin Receptor Peptides (TRP). ANGII is implicated in cardiovascular diseases, GnRH regulates production of sex steroids and TRP peptides are known as coagulation factors and cell function regulators. Therefore, conformational analysis of these peptides is very useful and has led to molecular models which are refined using conformational search methods and energy minimization calculations. Models are also useful for designing peptide | |
| References | 1. Kessler, H.: Angew. Chem. (Int. Ed.) 32: 543-544 (1993)
2. McCormic, D.: Biotechnology 10: 131 (1992) 3. Smeby, R.R., Fermandjian, S. In: Chemistry Biochemistry of Amino Acids, Peptides Proteins (Weinstein, B., ed.)t Vol. 5, pp. 117-148, Dekker, New York 4. Moore, GJ. In: Comprehensive Medicinal Chemistry (Emmett, J.C., ed.), Vol. 3, pp. 961-980, Pergamon Press, 1990 5. Matsoukas, J.M., Bigam, G., Zhou, N., Moore, G.J.: Peptides 11: 359-366 (1990) 6. Turner, R.J., Matsoukas, J.M., Moore, G.J.: Biochim. Biophys. Acta 106S: 21-28 (1991) 7. Rauk, A. Hamilton, G. and Moore, G.J. Biochim. Biophys. Res. Commun. 145: 1349-1353 (1987) 8. Carini, D.J. et al.: J. Med. Chem. 34: 2525-2547 (1991) 9. Wong, P.C. et al.: J. Pharmacol. Exp. Then. 34: 211- 217 (1990) 10. Moore, G.J., Franklin, K.J., Nystrom, D.M., Goghari, M.H.: Can. J. Physiol. Pharmacol. 63: 966-975 (1985) 11. Rees, D.C.: Annual Reports Med. Chem. 28: 59-68 (1993)
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1995 – ANNUAL SUBSCRIPTION 1995 | |
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