Title | The diastolic and systolic function of hypertrophic myocardium | |
Author | Constantine L. Papadopoulos
2nd Department of Cardiology, Aristotelian University of Thessaloniki, Greece |
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Citation | Papadopoulos, C.L.: The diastolic and systolic function of hypertrophic myocardium, Epitheorese Klin. Farmakol. Farmakokinet. 7(3): 101-107 (1993) | |
Publication Date | Received for publication: 25 October 1993
Accepted for publication: 5 November 1993 |
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Full Text Language | English | |
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Keywords | Hypertrophic myocardium, diastolic function, systolic function. | |
Other Terms | review article | |
Summary | In cardiac overload, myocardial hypertrophy represents the most efficient long-term compensatory mechanism; hypertrophy leads lately to heart failure because several disorders are gradually grown up within the hypertrophied myocardium resulting initially in diastolic and eventually in systolic dysfunction. The increased consumption and the impaired regeneration of ATP result in a decrease in the available ATP. Small ATP deficits lead to allosteric transformation of many functional proteins thus impairing their contribution in the diastolic and systolic processes. The mechanical effects of the hypertrophic myocardium and the hyperplastic connective tissue affect adversely relaxation, as well. Severe ATP deficit results in myocardial asystole and necrosis. Down regulation of β1 adrenoceptors, alteration in proteinic composition, altered membrane assembly and reappearance of foetal proteins contribute to the impairment of the systolic function. | |
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