| Title | Changes of lipid profile with the use of ω-3 fatty acids | |
| Authors | A. Salachas¹, C. Papadopoulos², G. Sakadamis², J. Styliades², R. Saynor¹, D. Oakley¹, D. Tsagadopoulos¹, C. Gitsios²
1. Cardiothoracic Unit, Nothern General Hospital, Sheffield S57AU, England 2. University Cardiology Dept. Ippokration Hospital, Thessaloniki, Greece |
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| Citation | Salachas, A., Papadopoulos, C., Sakadamis, G, Styliades, J., Saynor, R. et al: Changes of lipid profile with the use of ω-3 fatty acids, Epitheorese Klin. Farmakol. Farmakokinet. 7(3): 127-130 (1993) | |
| Publication Date | Received for publication: 1993
Accepted for publication: 1993 |
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| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €) pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | Normal lipid profile, ω-3 fatty acids. | |
| Other Terms | review article | |
| Summary | Ιn a double blind study, thirty nine patients with coronary heart disease were studied (mean age 54 range 30-79); twenty of them were treated with fish oil Maxepa 10 g daily and 19 with similar capsules of olive oil in the same dose (placebo group). Lipid analysis was performed before, at the 8 week and at the 12 week of the study. From the results of this study the following were observed: 1) The serum triglycerides decreased significantly in group A by 22% 8 weeks after starting treatment (p<0.01) and to a lesser degree 11% after 12 weeks of treatment (p:NS). In group B triglycerides slightly increased after 12 weeks of treatment. 2) No statistically significant changes were observed as regards total cholesterol, and HDL-cholesterol. 3) None of the patients complained of any side effects. It is concluded that Maxepa fish oil is a safe lipid lowering agent that has a favourable effect especially on the reduction of the triglycerides levels. | |
| References | 1. Bang, H.O., Dyerberg, J.: Lipid metabolism in Greenland Eskimos. In: Draper H.H. (ed). Adv. Nutr. Res, Plenum Press New York p.31 (1980)
2. Saynor, R., Verel, D. and Gillot, T.: EPA, bleeding time, platelets, serum lipids and G.T.N. consumption. Proc. VI Intern. Thrombosis. Haemostasis, Stockholm (1983) 3. Во-Zhu, and Parmley W: Modification of experimental and clinical atherosclerosis by dietary fish oil. Am. Hear. J. 119: 168 (1990) 4. Herald PM and Kinsella JE: Fish oil consumption and decreased risk of cardiovascular disease: a comparison of findings from animal and human feeding trial. Am. J. Clin. Nutr. 43: 566 (1986) 5. Mohta J, Lawson D and Saldeen Tom: Reduction in plasminogen activator inhibitor-1 (PAI-1) with omega-3 polyunsaturated fatty acid intake. Am Heart J 116: 1201 (1988) 6. Barcelli V, Gias-Greenwalt P, Pollack VE: Enhancing effect of dietary supplementation with ω-3 fatty acids on plasma fibrinolysis in normal subjects. Thromb. Res. 39: 307 (1985) 7. Braden AG, Knapp R, Fitzerald DF, Fitzerald AG: Dietary fish oil accelerates the response to coronary thrombolysis with tissue plasminogen activator. Circulation 82: 178 (1990) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1993 – ANNUAL SUBSCRIPTION 1993 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
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