Τόμος 12 (1998) – Τεύχος 1 & 2 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 12 (1998) – Issue 1 & 2 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title ANP as a mediator of antihypertensive drug action
Authors Constantine Papadopoulos¹ and Basil Kokkas²

1. 2nd Cardiology Department and 2. Laboratory of Pharmacology, Faculty of Medicine, Aristotle University of Thessaloniki, Greece

Citation Papadopoulos, C., Kokkas, B.: ANP as a mediator of antihypertensive drug action, Epitheorese Klin. Farmakol. Farmakokinet. 12(3): 3-8 (1998)
Publication Date Received for publication: 15 September 1997

Accepted for publication: 20 September 1997

Full Text Language English
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Keywords Arterial hypertension, angiotensin converting enzyme inhibitors, atrial natriuretic peptides, beta adrenergic blockers.
Other Terms review article
Summary Atrial natriuretic peptide (ANP) has a prominent role in the arterial pressure regulation and the same substance is involved in the antihypertensive action of some drugs. References data and authors’ observations derived from research protocols in patients with moderate hypertension indicate that β-adrenergic blockers as well as ACE inhibitors exert their antihypertensive action in part by increasing ANP secretion. There is also strong evidence that ANP secretion is inhibited by β1-adrenergic receptor stimulation but it is not affected by the stimulation of β2-one. On the other hand, the action of ACE inhibitors on plasma ANP levels is probably due to a reduced catabolism of this substance while an additional rote of bradykinine seems to be reasonable.
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