| Title | The antiproliferative action of organophosphate esters on cultured cell lines | |
| Authors | J. Flaskos1, W.G. McLean2 and A. J. Hargreaves3
1. Laboratory of Biochemistry and Toxicology, Faculty of Veterinary Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece 2. Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, U.K. 3. School of Life Sciences, The Nottingham Trent University, Nottingham, U.K. |
|
| Citation | Flaskos, J., McLean, W.G., Hargreaves, A.J.: The antiproliferative action of organophosphate esters on cultured cell lines, Epitheorese Klin. Farmakol. Farmakokinet. 12(3): 47-52 (1998) | |
| Publication Date | Received for publication: 10 December 1997
Accepted for publication: 10 January 1998 |
|
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
|
| Keywords | Organophosphate esters, cultured cell lines, antiproliferative effects. | |
| Other Terms | Statistical study | |
| Summary | The aim of this study was to assess the effects of four representative organophosphates (OPs), tricresyl phosphate (TCP), triphenyl phosphite (TPP), paraoxon (POX), and trichiorfon (TCL), on the proliferation of four cultured mammalian cell lines representative of the major cell types found in the nervous system. All OPs inhibited cell growth in a dose-dependent manner. However, TCP, which is the most potent inducer of delayed neuropathy in vivo exhibited the strongest antiproliferative effect on all cell lines. No apparent correlation between the antiproliferative potency of the drugs in vitro and their acute toxicity in vivo was found. The PC12 and N2A neuronal cell types gave very similar dose-response patterns when grown in the presence of the test OPs. | |
| References | 1. Hatch, R.C.: Poisons Causing Nervous Stimulation or Depression. In: Veterinary Pharmacology and Therapeutics (N.N. Booth, L.E. McDonald, eds), 6th ed., pp. 1053-1101. Iowa State University Press, Ames, Iowa, 1988
2. Weir, R.J., Hazelton, L.W.: Organic Phosphates. In: Patty’s Industrial Hygiene and Toxicology (G.D. Clayton. E.F. Clayton, eds), Vol. 2C, pp. 4801-4803, Wiley, New York, 1982 3. Johnson, M.K.: Organophosphorous esters causing delayed neurotoxic effects. Mechanism of action and structure/activity studies. Arch. Toxicol. 34: 259-288 (1975) 4. Johnson, M.K.: Organophosphates and delayed neuropathy – Is NTE alive and well? Toxicol. Appt. Pharmacol. 102: 385-389 (1990) 5. Abou-Donia, M.S., Lapadufa, D.M.: Mechanisms of organophosphorous-induced delayed neuropathy: Type I and II, Annu. Rev. Pharmacol. Toxicol. 30: 405-440 (1990) 6. Abou-Donia, M.B., Lapadula, D.M., Suwita, E.: Cytoskeletal proteins as targets for organophosphorous compounds and aliphatic hexacarbon-induced neurotoxicity. Toxicology 49: 469-477 (1988) 7. Flaskos, J., McLean, W.G., Hargreaves, A.J.: The toxicity of organophosphate compounds towards cultured nerve cells. Toxicol. Lett. 70: 71-76 (1994) 8. Suwita, E., Lapadula, D.M., Abou-Donia, M.B.: Calcium and calmodulin enhanced in vitro phosphorylation of hen brain cold-stable microtubules and spinal cord neurofilament triplet proteins after a single oral dose of tri-o-cresyl phosphate. Proc. Nail. Acad. Sci. USA 83: 6174-6178 (1986) 9. Knoth-Anderson, J., Veronesi, B., Jones, Κ., Lapadula, D.M., Abou-Donia, M.B.: Triphenyl phosphite-induced ultra-structural changes in bovine adrenomedullary chromaffin cells. Toxicol. Appl. Pharmacol. 112: 110-119 (1992) 10. Knoth-Anderson, J., Abou-Donia, M.B.: Differential effects of triphenyl phosphite and diisopropyl phosphofluoridate on catecholamine secretion from bovine adrenomedullary chromaffin cells. J. Toxicol. Env. Health 38: 103-114 (1993) 11. Dustin, P.: Microtubules. Springer Verlag, New York, 1984 12. Avila, J., Diaz-Nido, J., Wandoséll, F., Hargreaves, A.J., Hernandez, M.A., Serrano, L.: Phosphorylation of Tubulin by Different Protein Kinases. In: Structure and Function of the Cytoskeleton (B.A.F. Rousset, ed.), Colloque INSERM 171, pp. 439-445, John Libbey Eurotext Ltd, 1988 13. Pala, I., Vig, P.J., Desaiah, D., Srinivasan, A.: In vitro effects of organophosphorous compounds on calmodulin activity. J. Appl. Toxicol. 11: 391-395 (1991) 14. Sandmeyer, E.E., Kirwin, C.J.,Jr.: Esters. In: Patty’s Industrial Hygiene and Toxicology (G.D. Clayton, E.F. Clayton, eds), Vol. 2A, pp. 2259-2412, Wiley, New York, 1981 15. Sax, N.I.: Dangerous Properties of Industrial Materials. Van Nostrand Reinhold, New York, 1979 16. Osweiler, G.D., Carson, T.L., Buck, W.B., Van Gelder, G.A.: Clinical and Diagnostic Veterinary Toxicology, pp. 298-317, Kendall-Hurst Publishing Co., Dubuque, Iowa, 1985 |
|
| Relative Papers |
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1998 – ANNUAL SUBSCRIPTION 1998 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά, Γαλλικά – English, French |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|