| Title | The antiproliferative action of organophosphate esters on cultured cell lines | |
| Authors | J. Flaskos1, W.G. McLean2 and A. J. Hargreaves3
1. Laboratory of Biochemistry and Toxicology, Faculty of Veterinary Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece 2. Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, U.K. 3. School of Life Sciences, The Nottingham Trent University, Nottingham, U.K. |
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| Citation | Flaskos, J., McLean, W.G., Hargreaves, A.J.: The antiproliferative action of organophosphate esters on cultured cell lines, Epitheorese Klin. Farmakol. Farmakokinet. 12(3): 47-52 (1998) | |
| Publication Date | Received for publication: 10 December 1997
Accepted for publication: 10 January 1998 |
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| Full Text Language | English | |
| Order – Buy | pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | Organophosphate esters, cultured cell lines, antiproliferative effects. | |
| Other Terms | Statistical study | |
| Summary | The aim of this study was to assess the effects of four representative organophosphates (OPs), tricresyl phosphate (TCP), triphenyl phosphite (TPP), paraoxon (POX), and trichiorfon (TCL), on the proliferation of four cultured mammalian cell lines representative of the major cell types found in the nervous system. All OPs inhibited cell growth in a dose-dependent manner. However, TCP, which is the most potent inducer of delayed neuropathy in vivo exhibited the strongest antiproliferative effect on all cell lines. No apparent correlation between the antiproliferative potency of the drugs in vitro and their acute toxicity in vivo was found. The PC12 and N2A neuronal cell types gave very similar dose-response patterns when grown in the presence of the test OPs. | |
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