| Title | Utraviolet radiation and skin cancer implication of free radical reactions and reactive oxygen species in skin carcinogenesis | |
| Author | Athanasios Valavanidis
Chemistry Department, University of Athens, Athens, Greece |
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| Citation | Valavanidis, A.: Utraviolet radiation and skin cancer implication of free radical reactions and reactive oxygen species in skin carcinogenesis, Epitheorese Klin. Farmakol. Farmakokinet. 8(3): 101-117 (1994) | |
| Publication Date | Received for publication: 25 June 1994
Accepted for publication: 25 July 1994 |
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| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Ultraviolet radiation, free radical reactions, reactive oxygen species, skin carcinogenesis. | |
| Other Terms | review article | |
| Summary | Recent advances in experimental techniques and elucidation of important biological mechanisms provided adequate evidence for the involvement of free radicals in a variety of diseases. Free radicals are intrinsic components of the skin structure and more radicals are developing upon irradiation with ultraviolet radiation. The reactive oxygen species, which are developing with the combination of ultraviolet radiation and oxygen, initiate a series of free radical reactions leading to damaging attacks on cutaneous cells. Defense mechanisms in the skin exercise a very elaborate protection of its structure, but, when these defenses are overwhelmed by oxidative stress and prolonged exposure to UVR, then cutaneous damage is inevitable. Non-melanoma and melanoma skin cancers represent an important and steadily growing problem in many countries. There are numerous experimental data indicating that changing life styles and long-term exposure to sunlight contribute to increasing rates of photocarcinogenesis. The involvement of free radical reactions, or reactions initiated by them, in skin photocarcinogenesis can be proved indirectly from the reduced activity of antioxidant enzymic and non-enzymic mechanisms. Replenishment of skin antioxidants by dietary intervention reduces the rate of development of skin tumors in experimental animals. | |
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