Τόμος 8 (1994) – Τεύχος 3 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 8 (1994) – Issue 3 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Muscarinic receptor subtypes
Authors M.S. Jankovic¹, D. Kouvelas², A. Argiriou², V. Mirtsou-Fidani², T. Pavlidis², Ch. Papanikolau², P. Papaioannidou² and A.G. Paradelis²

1.  Department of Pharmacology, Medical Faculty, University Svetozar Markovic, Kragujevac, Serbia, FR Yugoslavia

2.  Department of Pharmacology, Medical Faculty, Aristotle University of Thessaloniki, Macedonia, Greece

Citation Jankovic, M.S., Kouvelas, D., Argiriou, A., Mirtsou-Fidani, V., Pavlidis, T. et al: Muscarinic receptor subtypes, Epitheorese Klin. Farmakol. Farmakokinet. 8(3): 118-126 (1994)
Publication Date Received for publication: 30 October 1994

Accepted for publication: 30 November 1994

Full Text Language English
Order – Buy  Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)

pharmakonpress[at]pharmakonpress[.]gr

Keywords Muscarinic receptors, subtypes, location, function.
Other Terms review article
Summary For over fifty years muscarinic receptor was considered to be of only one type. Recent advent of gene mapping and synthesis of great number of muscarinic antagonists enabled recognition of five different muscarinic receptor subtypes designated M1, M2, M3, M4 and M5. First four subtypes were characterised with selective agonists or antagonists, while M5 subtype was found only by genetical methods. M1, M3 and Msubtypes activate phospholipase C with subsequent formation of inositol-1,4,5-tris-phosphate as second messenger and release of Ca2+ from endoplasmic reticulum. M2 and M4 subtypes inhibit enzyme adenyl cyclase, decreasing concentration of cAMP intracellularly. AH subtypes of muscarinic receptor are present in central nervous system, while M2 subtypes predominate in heart and uterus. M1 and M3 receptors are prevalent in other smooth muscles, exocrine glands and blood vessels. Anyway, complete exclusion of some receptor subtypes in certain tissue is never possible.
References 1.    Fuder H., Meincke M.: Glycopyrronium bromide blocks differentially responses mediated by muscarinic receptor subtypes. Naunyn. Schmiedebergs. Arch. Pharmacol. 347(6): 591-595 (1993)

2.    Brann M.R., Ellis J., Jorgensen H., Hill-Eubanks D., Jones S.V.: Muscarinic acetylcholine receptor subtypes: localisation and structure/function. Prog. Brain. Res. 93: 121-127 (1993)

3.    Wang S.Z. and el-Fakahany E.E.: Application of transfected cell lines in studies of functional receptor subtype selectivity of muscarinic agonists. J. Pharmacol. Exp. Ther. 266(1): 237-243 (1993)

4.    Jones S.V.: Muscarinic receptor subtypes: modulation of ion channels. Life Sci. 52(5-6): 457-464 (1993)

5.    Caulfield M.P.: Muscarinic receptors – characterisation, coupling and function. Pharmacol. Ther. 58(3): 319-379 (1993)

6.    Parekh A.B. and Brading A.F.: The M3 muscarinic receptor links to three different transduction mechanisms with different efficacies in circular muscle of guinea-pig stomach. Br. J. Pharmacol. 106(3): 639- 643 (1992)

7.    Wojcikiewicz R.J., Furuichi T., Nakade S., Mikoshiba K. and Nahorski S.R.: Muscarinic receptor activation down-regulates the type I inositol-1,4,5- triphosphate receptor by accelerating its degradation. J. Biol. Chem. 269(11): 7963-7969 (1994)

8.    Maloteaux J.M. and Hermans E.: Agonist-induced muscarinic cholinergic receptor internalization, recycling and degradation in cultured neuronal cells. Cellular mechanisms and role in desensitisation. Biochem. Pharmacol. 47(1): 77-88 (1994)

9.    Mirzaev luR., Plotnikova I.T. and Shakirov R.: Ob osobennostih vliianiia imperialona na M-kholinoretseptory razlicnih organov. Eksp. KUn. Pharmacol. 56(4): 14-17 (1993)

10.  Lazareno S. and Birdsall N.J.: Pharmacological characterisation of acetylcholine – stimulated [35S]-GTP gamma S binding mediated by human muscarinic m1 – m4 receptors: antagonist studies. Br. J. Pharmacol. 109(4): 1120-1127 (1993)

11.  Lambrecht G., Moser U., Grimm U. et al.: New functionally selective muscarinic agonists. Life Sci. 52(5-6): 481-488 (1993)

12.  Fisher A., Heldman E., Gurwitz D. et al.: Selective signaling via unique M1 muscarinic agonists. Ann. N. Y. Acad. Sci. 695: 300-303 (1993)

13.  Eglen R.M., Harris G.C., Cox H., Sullivan A.O., Stefanich E. and Whiting R.L.: Characterization of the interaction of the cervane alkaloid, imperialine, with muscarinic receptors in vitro. Naunyn. Schmiedebergs. Arch. Pharmacol. 346(2): 144-151 (1992)

14.  Ten-Berge R.E., Roffel A.F. and Zaagsma J. The interaction of selective and non-selective antagonists with pre- and postjunctional muscarinic receptor subtypes in the guinea-pig trachea. Eur. J. Pharmacol. 233(2-3): 279-284 (1993)

15.  Yu M., Robinson N.E., Wang Z. and Derksen F.J.: Muscarinic receptor subtypes in equine tracheal smooth muscle. Vet. Res. Commun. 16(4): 301-310 (1992)

16.  Matera M.G., Cazzola M. and Rossi F.: Role of M1 muscarinic receptor subtypes in mediating airway smooth muscle contraction, int. J. Tissue. React. 15(1): 31-35 (1993)

17.  Mak J.C., Baraniuk J.N. and Barnes P.J.: Localisation of muscarinic receptor subtype mRNAs in human lung. Am. J. Respir. Cell. Mol. Biol. 7(3): 344- 348 (1992)

18.  Haddad E.B., Mak J.C., Hislop A., Haworth S.G. and Barnes P.J.: Characterisation of muscarinic receptor subtypes in pig airways: radioligand binding and northern blotting studies. Am. J. Physiol. 266(6 Pt 1): L642-648 (1994)

19.  Roets E., Burvenich C. and Roberts M.: Muscarinic receptor subtypes, beta-adrenoceptors and cAMP in the tracheal smooth muscle of conventional and double-muscled calves. Vet. Res. Commun. 16(6): 465-476 (1992)

20.  Barnes P.J.: Muscarinic receptor subtypes in airways. Life Sci. 52(5-6): 521-527 (1993)

21.  Ishihara H. and Shimura S.: The role of muscarinic receptor subtypes in feline tracheal submucosal gland secretion. Nippon. Kyobu. Shikkan. Gakkai. Zasshi. 30 Suppl: 65-69 (1992)

22.  Mullol J., Baraniuk J.N., Logun C. et al.: M1 and М3 muscarinic antagonists inhibit human nasal glandular secretion in vitro. J. Appl. Physiol. 73(5): 2069-2073 (1992)

23.  Okayama M., Mullol J., Baraniuk J.N. et al.: Muscarinic receptor subtypes in human nasal mucosa: characterisation, autoradiographic localization, and function in vitro. Am. J. Respir. Cell. Mol. Biol. 8(2): 176-187 (1993)

24.  Cosentino M., De-Ponti F., D’ Angelo L. and Crema A.: Motility of rabbit proximal colon. Relevance of cholinergic pathways and role of different muscarinic receptor subtypes. Dig. Dis. Sci. 37(11): 1746-1753 (1992)

25.  Blanquet F., Abysique A. and Gonella J. In vivo study of the role of muscarinic receptors in the para-sympathetic control of rabbit colonic motility. J. Auton. Nerv. Syst. 46(3): 217-227 (1994)

26.  Gomez A., Martos F., Bellido I. et al.: Muscarinic receptor subtypes in human and rat colon smooth muscle. Biochem. Pharmacol. 43(11): 2413-2419 (1992)

27.  Jankovic M.S.: Pharmacological analysis of muscarinic receptor subtypes in the smooth muscle from gastric corpus. PhD thesis, Medical Faculty, University of Belgrade (1993)

28.  Yokotani K., Okuma Y., Nakamura K. and Osumi Y.: Release of endogenous acetylcholine from a vascularly perfused rat stomach in vitro; inhibition by M3 muscarinic autoreceptors and alpha-2 adrenoceptors. J. Pharmacol. Exp. Ther. 266(3): 1190-1195 (1993)

29.  Yokotani K. and Osumi Y.: Cholinergic M2 muscarinic receptor – mediated inhibition of endogenous noradrenaline release from the isolated vascularly perfused rat stomach. J. Pharmacol. Exp. Ther. 264(1): 54-60 (1993)

30.  Shida T., Tokunaga A., Kondo E. et al.: Expression of muscarinic and nicotinic receptor mRNA in the salivary glands of rats: a study by in situ hybridization histochemistry. Brain. Res. Mol. Brain. Res. 17(3-4): 335-339 (1993)

31.  Watson G.E. and Culp D.J.: Muscarinic cholinergic receptor subtypes in rat sublingual glands. Am. J. Physiol. 266(2 Pt 1): C335-342 (1994)

32.  Kato M., Ohkuma S., Kataoka K., Kashima K. and Kuriyama K.: Characterisation of muscarinic receptor subtypes on rat pancreatic acini: pharmacological identification by secretory responses and binding studies. Digestion. 52(3-4): 194-203 (1992)

33.  Ogle C.W., Qiu B.S. and Cho C.H.: Nicotine and gastric ulcers in stress. J. Physiol. Paris. 87(6): 359- 365 (1993)

34.  Kajimura M., Reuben M.A. and Sachs G.: The muscarinic receptor gene expressed in rabbit parietal cells is the M3 subtype. Gastroenterology. 103(3): 870-875 (1992)

35.  Ren L.M., Nakane T. and Chiba S.: Muscarinic receptor subtypes mediating vasodilation and vasoconstriction in isolated, perfused simian coronary arteries. J. Cardiovasc. Pharmacol. 22(6): 841-846 (1993)

36.  Yamanoue T., Brum J.M., Estafanous F.G., Khairallah P.A. and Ferrario C.M.: Fentanyl attenuates porcine coronary arterial contraction through M3-muscarinic antagonism. Anesth. Analg. 76(2): 382-390 (1993)

37.  Altiere R.J., Travis D.C., Roberts J. and Thompson D.C.: Pharmacological characterisation of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries. J. Pharmacol. Exp. Ther. 270(1): 269-276 (1994)

38.  Bruning T.A., Hendriks M.G., Chang P.C., Kuypers E.A. and van-Zwieten P.A.: In vivo characterisation of vasodilating muscarinic-receptor subtypes in humans. Circ. Res. 74(5): 912-919 (1994)

39.  Dauphin F., Linville D.G. and Hamel E.: Cholinergic dilatation and constriction of feline cerebral blood vessels are mediated by stimulation of phosphoinositide metabolism via two different muscarinic receptor subtypes. J. Neurochem. 63(2): 544-551 (1994)

40.  Yang C.M., Yeh H.M., Sung T.C., Chen F.F. and Wang Y.Y.: Characterisation of muscarinic receptor subtypes in canine left ventricular membranes. J. Recept. Res. 12(4): 427-449 (1992)

41.  Hassall C.J., Stanford S.C., Burnstock G. and Buckley N.J.: Co-expression of four muscarinic receptor genes by the intrinsic neurons of the rat and guinea-pig heart. Neuroscience. 56(4): 1041-1048 (1993)

42.  Doods H.N., Willim K.D., Boddeke H.W. and Entzeroth M.: Characterisation of muscarinic receptors in guinea-pig uterus. Eur. J. Pharmacol. 250(2): 223-230 (1993)

43.  Hernandez M., Simonsen U., Prieto D. et al.: Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br. J. Pharmacol. 110(4): 1413-1420 (1993)

44.  Matsuno K. and Mita S.: Involvement of the muscarinic receptors in the postsynaptic potentiation of neurogenic twitch contraction in the mouse vas deferens. Life Sci. 50(11): 799-806 (1992)

45.  Bernheim L., Mathie A. and Hille B.: Characterization of muscarinic receptor subtypes inhibiting Ca2+ current and M current in rat sympathetic neurons. Proc. Natl. Acad. Sci. USA. 89(20): 9544- 9548 (1992)

46.  Aguilar J.S., Ballesta J.J., Reig J.A., Palmero M., Viniegra S. and Criado M.: Muscarinic receptor subtypes in bovine adrenal medulla. Neurochem. Res. 17(12): 1235-1239 (1992)

47.  Hersch S.M., Gutekunst C.A., Rees H.D., Heilman C.J. and Levey Al.: Distribution of m1 – m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies. J. Neurosci. 14(5 Pt 2): 3351-3363 (1994)

48.  Bogdanovic N., Islam A., Nilsson L., Bergstrom, L., Winblad B. and Adem A.: Effects of nucleus basalis lesion on muscarinic receptor subtypes. Exp. Brain. Res. 97(2): 225-232 (1993)

49.  Flynn D.D. and Mash D.C.: Distinct kinetic binding properties of N-[3H]-methylscopolamine afford differential labeling and localization of M1, M2, and M3 muscarinic receptor subtypes in primate brain. Synapse. 14(4): 283-296 (1993)

50.  Bartolini A., Ghelardini C., Fantetti L., Malcangio, M., Malmberg-Aiello P. and Giotti A.: Role of muscarinic receptor subtypes in central antinociception. Br. J. Pharmacol. 105(1): 77-82 (1992)

51.  Zheng J.L., Bian C.F., Qin W. and Yu A.Y.: Muscarinic receptor subtypes in respiratory center and their functions. Chung. Kuo. Yao. Li. Hsueh. Pao. 13(4): 349-354 (1992)

52.  Doods H.N., Quirion R., Mihm G. et al.: Therapeutic potential of CNS-active Mantagonists: novel structures and pharmacology. Life Sci. 52(5- 6):497- 503 (1993)

53.  Vilaro M.T., Palacios J.M. and Mengod G.: Multiplicity of muscarinic autoreceptor subtypes? Comparison of the distribution of cholinergic cells and cells containing mRNA for five subtypes of muscarinic receptors in the rat brain. Brain. Res. Mol. Brain. Res. 21(1-2): 30-46 (1994)

54.  Imeri L., Bianchi S., Angeli P. and Mancia M.: Selective blockade of different brain stem muscarinic receptor subtypes: effects on the sleep-wake cycle. Brain. Res. 636(1): 68-72 (1994)

55.  Zubieta J.K. and Frey K.A.: Autoradiographic mapping of M3 muscarinic receptors in the rat brain. J. Pharmacol. Exp. Ther. 264(1): 415-422 (1993)

56.  Drescher D.G., Upadhyay S., Wilcox E. and Fex J.: Analysis of muscarinic receptor subtypes in the mouse cochlea by means of polymerase chain re-action. J. Neurochem. 59(2): 765-767 (1992)

57.  Martin J.R.: Pressor response to posterior hypothalamic administration of carbachol is mediated by muscarinic M3 receptor. Eur. J. Pharmacol. 215(1): 83-91 (1992)

Relative Papers

Online ISSN 1011-6575

Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:

Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor

Τι είναι η Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση-Οδηγίες προς τους Συγγραφείς – 
What is Epitheorese Klinikes Farmakologias 
και Farmakokinetikes-International Edition-Instrunctions to Authors

Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – 
Articles Published in Epitheorese Klinikes Farmakologias 
και Farmakokinetikes-International Edition

Συντακτικη Επιτροπή-Editorial Board

ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1994 – ANNUAL SUBSCRIPTION 1994
Γλώσσα Πλήρους Κειμένου – Full Text Language Αγγλικά, Γαλλικά – English, French
Παραγγελία – Αγορά – Order – Buy Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)

pharmakonpress[at]pharmakonpress[.]gr

Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)

pharmakonpress[at]pharmakonpress[.]gr

 

 

 

 

Bookmark the permalink.

Comments are closed.