Title | Cellular mechanisms of vasomotion | |
Authors | Constantine L. Papadopoulos1 and Basile A. Kokkas²
1. 2nd Dept, of Cardiology, 2. Laboratory of Experimental Pharmacology, Faculty of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Macedonia, Greece |
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Citation | Papadopoulos, C.L., Kokkas, B.A.: Cellular mechanisms of vasomotion, Epitheorese Klin. Farmakol. Farmakokinet. 8(3): 127-133 (1994) | |
Publication Date | Received for publication: 10 November 1994
Accepted for publication: 30 November 1994 |
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Full Text Language | English | |
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Keywords | Vasomotion, cellular mechanisms. | |
Other Terms | review article | |
Summary | Intracellular free calcium is the final mediator of vascular smooth muscle contraction, its delivery and effectiveness is regulated by several intracellular factors affecting the entry, the release from sarcoplasmic reticulum and the degree of activation of the enzyme-targets. Membrane potential and the chum oral factors IP3, DAG, cAMP and cGMP, and DAG are the main mediators of the regulation. Membrane potentials and intracellular synthesis as well as Ca2+ channel conductance are controlled by the activation of several sarcolemmal receptors and their effect on G proteins. These receptors are targets for a vast number of neurotransmitters and autocrine, paracrine and hormonal substances. The effect of the vasomotor agents is modified by endothelium paracrinic function. Finally the release of neurotransmitters is regulated by several feedback mechanisms. | |
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