Τόμος 10 (1996) – Τεύχος 1 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 10 (1996) – Issue 1 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

By | | Άρθρο επισκόπησης - Review Article, Β. Ταρλατζής - B. Tarlatzis, Βασίλειος Α. Κόκκας - B. Kokkas, Γ. Μπόντης - J. Bontis, Γ. Πάγκαλος - G. Pangalos, Γ. Παπαδήμας - J. Papadimas, Ε. Μπίλη - E. Bili, Ε. Σπανός - E. Spanos, Πλήρες Κείμενο στα Αγγλικά - Full Text in English, Σ. Μανταλενάκης - S. Mantalenakis, Φ. Παπαδοπούλου - F. Papadopoulou
Title Testosterone undecanoate versus mesterolone in hypogonadal male patients
Authors J. Papadimas, E. Bili, F. Papadopoulou, E. Spanos, B. Tarlatzis, B. Kokkas, G. Pangalos, J. Bontis and S. Mantalenakis

1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thes­saloniki, Greece
Citation Papadimas, J., Bili, E., Papadopoulou, F., Spanos, E., Tarlatzis, B. et al: Testosterone undecanoate versus mesterolone in hypogonadal male patients, Epitheorese Klin. Farmakol. Farmakokinet. 10(1): 3-8 (1996)
Publication Date Received for publication: 10 October 1995Accepted for publication: 25 October 1995
Full Text Language English
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Keywords Testosterone undecanoate, mesterolone, hopogonadal male patients.
Other Terms review article
Summary A randomized, double-blind, group comparative study was performed in 16 hypogonadal mate patients in order to compare the effects on hormone plasma levels, on sexual activity and mental state of testosterone undecanoate (TU) and mesterolone (M). The TU-treated group consisted of 9 patients and the M-treated group consisted of 7 patients. Plasma testosterone (T), dihydrotestosterone (DHT), a-estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and dehydroepiandrosterone sulfate (DHEA-S) levels were evaluated before and during treatment with TU or M for 4 weeks. Moreover, libido, sexual activity and mental state were assessed and scored according to well accepted criteria. The daily dose of TU was 120 mg and of M 75 mg. TU induced a significant rise of T, DHT, E2 and DHEA-S, while FSH, LH and PRL levels remained unchanged. TU induced also a marked improvement of the sexual activity and mental state.
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