Title | Exposure to fibrous and nonfibrous respirable dusts, generation of oxygen free radicals and occupational lung diseases: an introductory review | |
Authors | Athanasios Valavanidis, Anna Theodoropoulou and Dimitra Houhoula
Department of Chemistry, University of Athens, University Campus Zografou, 15771 Athens, Greece |
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Citation | Valavanidis, A., Theodoropoulou, A., Houhoula, D.: Exposure to fibrous and nonfibrous respirable dusts, generation of oxygen free radicals and occupational lung diseases: an introductory review, Epitheorese Klin. Farmakol. Farmakokinet. 10(3): 99-119 (1996) | |
Publication Date | Received for publication: 15 July 1996
Accepted for publication: 10 September 1996 |
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Full Text Language | English | |
Order – Buy | pharmakonpress[at]pharmakonpress[.]gr | |
Keywords | Fibrous and nonfibrous respirable dusts, occupational exposures, oxygen free radicals, oxidative damage, occupational lung diseases. | |
Other Terms | review article | |
Summary | Exposure to fibrous and nonfibrous minerals, inorganic dusts, coal and other respirable particles as air pollutants can cause chronic nonmalignant and malignant pulmonary diseases. Numerous epidemiological studies established the type and extent of pulmonary damage to workers from exposure to such dusts as silica, quartz, coal, asbestos, talc, sand, fly ash etc. Respirable particles of these dusts can reach the alveoli and respiratory bronchioles of the lungs where they can cause cell injury and progressively lead to adverse health effects. Research in this field contributed to our understanding of the mechanisms of cytotoxicity in dusty occupations and the form of occupational diseases. The role of oxygen free radicals and reactive oxygen species, generated by fibrous and nonfibrous respirable dusts is proved to be crucial to the initial cell injury. Also, the release of alveolar macrophages (pulmonary defenses) to engulf and digest the foreign particles can contribute to the damage of alveolar epithelium. Smoking is another important factor. The synergistic effect of cigarette smoking, which contains a great number of free radicals, carcinogens and mutagens, can substantially increase the extent of adverse pulmonary health effects. In this introductory review some basic concepts of the free radical research, and the exploration of mechanisms of cytotoxicity by fibrous and nonfibrous respirable particles have been collected, together with various biological and epidemiological studies concerned with the occupational lung diseases in dusty workplaces. | |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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