| Title | Treatment of hypertensive crisis in outpatients with drug combinations: case report | |
| Authors | Slobodan M. Jankovic¹, Aleksandar Klickovic², Jovica Ustevic², Dimitrios Kouvelas³ and Vassiliki Mirtsou-Fidani³
1. Center for Clinical and Experimental Pharmacology, Clinical Hospital Center, Kragujevac, Serbia, FR Yugoslavia 2. Emergency Unit, Medical Center, Kragujevac, Serbia, FR Yugoslavia 3. Department of Pharmacology, Medical Faculty, Aristotle University of Thessaloniki, Greece |
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| Citation | Jankovic, S.M., Klickovic, A., Ustevic, J., Kouvelas, D., Mirtsou-Fidani, V.: Treatment of Hypertensive Crisis in Outpatients with Drug Combinations: Case Report, Epitheorese Klin. Farmakol. Farmakokinet. 10(3): 127-130 (1996) | |
| Publication Date | Received for publication: 10 November 1996
Accepted for publication: 1 December 1996 |
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| Full Text Language | English | |
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| Keywords | Hypertensive emergency, outpatients, dihydroergotoxin, nifedipine, furosemide. | |
| Other Terms | review article | |
| Summary | Hypertensive emergencies should be treated promptly, using drugs that rapidly tower blood pressure. However, too rapid decrease of the pressure could be accompanied with sudden death. In our study we heave used combinations of three drugs: nifedipine (10 mg orally), dihydroergotoxin (0.3 mg intravenously) and furosemide (20 mg intravenously). Due to technical reasons, all patients were treated on outpatient basis, in their homes. The response was good in patients receiving combinations of three (8 patients) or two (8 patients) of upper drugs. The blood pressure was towered gradually within 40 minutes, and remained towered for next 12 hours. There was no significant reflex tachicardia after drug administration (pulse rate was below 100/minute in all patients). On the other hand, two patients who received only one of the drugs did not have their blood pressure towered enough. The results of our study suggest that combination of two or three antihypertensive drugs with tower efficiency could be safe option for treatment of hypertensive crisis on outpatient basis. | |
| References | 1. Reynolds E.F.J.: Martindale The Extra Pharmacopoeia. 30th edition, Pharmaceutical Press, London, pp. 2363; 1993
2. Foley J.J.: Pharmacologic management of hypertensive crisis in the emergency department. J. Emerg. Nurs. 20: 134-15 (1994) 3. Warner R.R., Mani S., Profeta J., Grunstein E.: Octreotide treatment of carcinoid hypertensive crisis. Mt Sinai J. Med. 61: 349-355 (1994) 4. Sulbaran T., Apaficio J., Bermudez G.: Uso del captopril sublingual en crisis hipertensivas. Invest Clin 35: 143-154 (1994) 5. McAlister F.A., Lewanczuk R.: Hypertensive crisis after discontinuation of angiotensin-converting enzyme inhibitor (letter). Lancet 344: 1502 (1994) 6. Kawabata K., Maktno H, Nagake Y., Morita Y., Akiyama K., Ota K., Sugimoto H., Ikeda S., Ota Z.: A case of scleroderma renal crisis with acute interstitial pneumonia, microangiopathic hemolytic anemia and refractory thrombo-cytopenia. Nippon Jinzo GakkaiShi. 36: 1067-1074 (1994) 7. McKindley DS, Boucher BA. Advances in pharmacotherapy: treatment of hypertensive crisis. J Clin. Pharm. Ther. 19: 163-80 (1994) 8. Isles CG. Management of hypertensive crises. Scott Med J 40: 23-5 (1995) |
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Online ISSN 1011-6575
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