Title | Nucleotidyl-tyrosine and nucleotidyl-peptides containing tyrosine hydrolysis by various enzymes, separation and characterization by HPLC | |
Authors | M. Liakopoulou-Kyriakides1, C.A. Tsoleridis2, A.A. Pantazaki2, and A. Metaxas1
1. Department of Chemical Engineering, Section of Chemistry, 2. Department of Chemistry, Section of Organic Chemistry and Biochemistry, Aristotle University of Thessaloniki, Thessaloniki, 54006, GREECE |
|
Citation | Liakopoulou-Kyriakides, M., Tsoleridis, C.A., Pantazaki, A.A., Metaxas, A.: Nucleotidyl-tyrosine and nucleotidyl-peptides containing tyrosine hydrolysis by various enzymes, separation and characterization by HPLC, Epitheorese Klin. Farmakol. Farmakokinet. 13(1): 43-48 (1999) | |
Publication Date | Accepted for publication: 17 June 1999 | |
Full Text Language | English | |
Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
|
Keywords | Nucleotides-tyrosine, nucleotides-peptides, esterases, phosphatases, HPLC. | |
Other Terms | review article | |
Summary | A series of derivatives of tyrosine and peptides containing tyrosine with uridine-5′-monophosphate and thymidine-5′-monophosphate, through the functional hydroxyl group of tyrosine, were synthesized by the dicyclo-hexylcarbodiimide method in pyridine at 35-40 °C. The effect of various esterases on the stability of the phosphoester bond was investigated. The products were purified and characterized by HPLC and/or other spectroscopic techniques. | |
References | 1. Juodka B.A.: Nucleosides and Noucleotides. Covalent interaction of proteins and nucleic acids. Synthetic and natural noudeotide-peptides. 3: 445-483 (1984)
2. Akashi S., Ishihara H.: Amino acids present in yeast ribonucleic acid in the bound form. I Liberation of amino acids from RNA by alkaline treatment. J. Biochem. 45: 927-931 (1960) 3. Goto H.: Amino acids in yeast RNA in bound form. Ill Dinitrophenylation studies on the purified yeast RNA. J. Biochem, (Tokyo) 56: 328-333 (1964) 4. Ingram V.M., Sullivan E.: Amino acids in yeast acceptor ribonucleic acid. Biochim. Biophys. Acta 61: 583-587 (1962) 5. Ball’s M.E., Safser J.S., Eider A.: Suggested role of amino acids from RNA by alkaline treatment. Nature 203: 1170-1174 (1964) 6. Salser J.S., Balis M.E.-. Amino acids bound to DNA. Biochim. Biophys. Acta 149: 220-227 (1967) 7. Olenick J.G., Hahn F.E.: Amino acids in hydrolyzates of deoxyribonucleic acid of E coli. ibid 87: 535-539 (1964) 8. Webb S.J.: The influence of growth media on proteins bound to DNA and their possible response of E.coli B to ultraviolet light. Can. J. Microbiol. 13: 57-62 (1967) 9. Salser J.S., Balis M.E.: Amino acids associated with DNA of tumors. Cancer Res. 23: 595-560 (1968) 10. Robins M.J., Simon L.N., Stout M.E., Ivanovich G.A., Schweizer M.P., Rousseau R.S., Robins R.K.: Nucleoside peptides. I The synthesis of 5′-deoxy-5′-amino-5′-N-ami- noacyl peptide derivatives of guanosine, adenosine and 2′- deoxyadenosine and their effect on cell-free protein synthesis. J. Am. Chem. Soc. 93: 4387-4392 (1971) 11. Ivanovich G.A., Rousseau R.J., Robins R.K.: Nucleoside peptides: Synthesis of certain S-N-aminoacyl and S-N peptidyl derivatives of S-amino-uridine. J. Med. Chem. 14: 1155-1158 (1971) 12. Sharipo B.M., Stadtman E.R.: 5’-Adenylyl-O-tyrosine. The novel phosphodiester residue of adenylylated glutamine synthetase from E coli. J. Biol. Chem. 243: 3769- 3771 (1968) 13. Juodka B.A., Kirreliene V.A., Porilinis P.S.: Oligonu-cleotides and nucleotide-peptides. Synthesis and properties of nucleotidyl(P-O)amino acids (peptides) and their esters. Nucleosides and Nucleotides, 1(2): 112-125 (1982) 14. Schattenkerk C., Wreesmaan C.T.J., de Graaf M.J., van der Marel G.A., van Boom J.H.: Synthesis of a naturally occuring nucleopeptide fragment via a phosphotriester approach. Tetrahedron Letters 45: 5197-5200 (1984) 15. Kuyl-Yeheskiely E., Tromp C.M., Schaeffer A.H., van der Marel G.A., van Boom J.H.: A model study directed towards the preparation of nucleopeptides via H-phosphonate intermediates. Nucl. Acids Res. 15: 1807-1817 (1987) 16. Michelson A.M.: Synthesis of nucleoside 5′-pyrophosphates. J. Chem. Soc.: 1957-1963 (1958) |
|
Relative Papers |
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1999 – ANNUAL SUBSCRIPTION 1999 | |
Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |