Τόμος 14 (2000) – Τεύχος 3 – Άρθρο 5 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 14 (2000) – Issue 3 – Article 5 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title The influence of olive oil diet on atherogenic factors in rats
Authors N. Kazanas, A. Potamianou, C. Gourna, I. Nikolidakis and C. Tesserommatis

Department of Experimental Pharmacology, Medical School, University of Athens, Greece, Goudi 11527

Citation Kazanas, N., Potamianou, A., Gourna, C., Nikolidakis, I., Tesserommatis, C.: The influence of olive oil diet on atherogenic factors in rats, England and Wales: the smoking case study, Epitheorese Klin. Farmakol. Farmakokinet. 14(3): 131-144 (2000)
Publication Date Received for publication: 25 June 2000

Accepted for publication: 20 August 2000

Full Text Language English
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Keywords Atherosclerosis, cytokine, endothelium, olive oil, oxidation, rats.
Other Terms review article
Summary The vascular endothelium is related to the pathogenesis of cardiovascular diseases by the mediation of cytokines, which activate the adhesion of neutrophiles and eosinophiles in endothelial cells. The loss of endothelium integrity during the chronic inflammatory changes of the atheromatic disease is reflected on the elevation of the cytokine levels in plasma. Besides cholesterol, the elevation of plasma fibrinogen levels is well established as risk factor for cardiovascular disease. In this study, the protective role of olive oil diet in relation to the mechanism of endothelium dysfunction is investigated via the changes of fibrinogen, antithrobin- III, cholesterol and cytokines (IL-1a, IL-6, IL-8, TNFa). A detectable amelioration of the high-risk parameters of the atheromatic disease development is observed after consumption of olive oil, while the opposite is noted on the cytokine levels. The defensive role of the olive oil on the progression of lesions of the vascular endothelium and the thrombotic complications during the atherogenetic process might be owed to the activation of immune responses, mediated by the cytokines, but a further investigation of the oxidative and coagulation events is needed.
References 1.     Prediman K. Shah: Plaque and the Coronary Thrombosis: New insight into pathogenesis and prevention. Clin. Cardiol. 20 (Suppl. II): 38-44 (1997)

2.     Yazdani S., Simon A.D., Vidhun R., Gulotta C., Schwartz A., Rabbani L.E.: Inflammatory profile in unstable angina versus stable angina in patients undergoing percutaneous interventions. Am. Heart J. 136: 357-361 (1998)

3.     Juvonen J., Surcel H.M., Satta J., Teppo A.M., Bloigu A., Syrjala H., Airaksinen J., Leinonen M., Saikku P., Juvonen T.: Elevated circulating levels of inflammatory cytokines in patients with abdominal aortic aneurysm. Arterioscler. Thromb. Vase. Biol. 17: 2843-2847 (1997)

4.     Fogari R., Zoppi A., Marasi G., Vanasia A., Villa G.: Associations between plasma fibrinogen levels and cardiovascular risk factors in hypertensive men. J. Cardiovasc. Risk 1: 341-345 (1994)

5.     Dotevall A., Johansson S., Wilhelmsen L: Association between fibrinogen and other risk factors for cardiovascular disease in men and women. Results from the Goteborg MONICA survey 1985. Ann. Epidemiol. 4: 369-374 (1994)

6.     Chisolm G.M., Penn M.S.: Oxidized lipoproteins and Atherosclerosis. In: Atherosclerosis and Coronary Artery Disease (V. Foster, R. Ross, E.J. Topol, eds), Ch. 8, Lippincott, Raven Publishers, Philadelphia, 1996

7.     Sundker G.W., Kromhout D„ Aravanis C., Bloemboerg B.P., Mensink R.P., Karalias N., Katan M.B.: Serum cholesteryl ester fatty acids and their relation with serum lipids in elderly men in Crete and The Netherlands. Eur. J. Clin. Nutr. 47: 201-208 (1993)

8.     Visioli F., Galli C.: Olive oil phenols and their potential effects on human health. J. Agric. Food Chem. 46. 4292 (1998)

9.     Ciappellano S., Simmonetti P., Brighenti F., Bermano C., Testolin G.: Some nutritional benefits of extra virgin olive oil. Grasas y Aceites 45: 48 (1994)

10.    Stampfer M.J., Hennekens C.H., Manson G.E., Colditz G.A., Rosner B., Willet W.C.: Vitamin E consumption and the risk of coronary disease in women. N. Engl. J. Med. 326: 1444-449 (1993)

11.    Rimm E.B., Stampfer M.J., Ascherio A., Giovannucci E., Colditz G.A., Willet W.C.: Vitamin E consumption and the risk of coronary disease in men. N. Engl. J. Med. 326: 1450-1456(1993)

12.    Grundy S.M.: Lipids, nutrition and coronary heart disease. in: Atherosclerosis and Coronary Artery Disease (V. Fuster, R. Ross, and E.J. Topol, eds), Ch 4, Lippincott- Raven Publishers, Philadelphia, 1996

13.  Vonica A., Vagaonescou T., Cristea A., Standoiu N.: Functional and antigenic AT-III in angina pectoris and acute myocardial infraction patients. Med. Intern. 26: 311- 317(1990)

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