Title | Molecular genetic dissection of glucocorticoid receptor function by gene targeting | |
Authors | Stefan Berger, Wolfgang Schmid and Günther Schütz
German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg Germany |
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Citation | Berger, S., Schmid, W., Schütz, G.: Molecular genetic dissection of glucocorticoid receptor function by gene targeting, Epitheorese Klin. Farmakol. Farmakokinet. 18(2): 208-211 (2004) | |
Publication Date | Accepted for publication: 2004 | |
Full Text Language | English | |
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Keywords | – | |
Other Terms | review article | |
Summary | – | |
References | 1. Greiner E., Wintermantel T., Schütz G.: Steroid Receptors. In: Handbook of Experimental Pharmacology (S. Offermanns, L. Hein, eds). Springer-Verlag, Heidelberg, 2003
2. Miller W.L., Blake Tyrrel J.: (1995). The adrenal cortex. In: Endocrinology and Metabolism (P. Felig, J.D. Baxter, L.A. Frohman, eds). Pp. 555-711, McGraw-Hill Inc., 1995 3. Gu H., Marth J.D., Orban P.C., Mossmann H., Rajewski K.: Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265: 103-106 (1994) 4. Sauer B., Henderson N.: Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc. Natl. Acad. Sei. USA 85: 5166-5170 (1988) 5. Beato M., Herrlich P., Schütz G.: Steroid hormone receptors: many actors in search of a plot. Cell 83: 851-857 (1995) 6. Kellendonk C., Tranche F., Reichardt H., Bauer A., Greiner E., Schmid W., Schütz G.: Analysis of glucocorticoid receptor function in the mouse by gene targeting. In: Recent Advances in Glucocorticoid Receptor Action (A.C. Cato, K. Asadullah, eds). Pp. 305-318, Springer, Berlin, 2002 7. Cole T.J., Blendy J.A., Monaghan A.P., Krieglstein K., Schmid W., Aguzzi A., Fantuzzi G., Hummler E., Unsicker K., Schutz G.: Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 9: 1608-2116 (1995) 8. Tranche F., Kellendonk C., Reichardt H.M., Schütz G.: Genetic dissection of glucocorticoid receptor function in mice. Curr. Opin. Genet. Dev. 8: 532-538 (1998) 9. Diamond M.I., Miner J.N., Yoshinaga S.K., Yamamoto K.R. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249: 1266-1272(1990) 10. Jonat C., Rahmsdorf H.J., Park K.K., Cato A.C., Gebel S., Ponta H., Herrlich P.: Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62: 1189-1204 (1990) 11. Reichardt H.M., Kaestner K.H., Wessely O., Tuckermann J., Angel P., Kretz O., Bock R., Schmid W., Herrlich P., Schütz G.: DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93: 1-20 (1998) 12. Heck S., Kulimann M., Gast A., Ponta H., Rahmsdorf H.J., Herrlich P., Cato A.C.: A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 13: 4087-4095 (1994) 13. Reichardt H.M., Tuckermann J.P., Göttlicher M., Vujic M., Weih F., Angel P., Herrfich P., Schütz G.: Repression of inflammatory responses in the absence of DNA-binding by the glucocorticoid receptor. EMBO J. 20: 7168-7173 (2001) 14. Tranche F., Kellendonk C., Kretz O., Gass P., Anlag K., Orban P.C., Bock R., Klein R., Schütz G.: Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat. Genet. 23: 99-103 (1999) 15. Kellendonk C., Opherk C., Anlag K., Schütz G., Tronche F.: Hepatocyte-specific expression of Cre recombi-nase. Genesis 26: 151-153 (2000) 16. MacGillivray M.H.: The adrenal cortex, ln: Endocrinology and Metabolism (P. Felig, J.D. Baxter, L.A. Frohman, eds). Pp. 1619-1673, McGraw-Hill Inc., 1995 17. Chow J. C., Ling P. R., Qu Z., Laviola L, Ciccarone A., Bistrian B.R., Smith R.J.: Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo. Endocrinology 137: 2880-2886 (1996) 18. Stöcklin E., Wissler M., Goullieux F., Groner B.: Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383: 726-728 (1996) 19. Reichardt H.M., Umland T., Bauer A., Kretz O., Schütz G.: Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock. Mol, Cell. Biol. 20: 9009-9017 (2000) |
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Online ISSN 1011-6575
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