Title | DNA microarray techniques review | |
Authors | Stavros Glentis¹, Ian Craft², Alan Thornhill² and Joyce C. Harper¹
1. Department of Obstetrics and Gynaecology, University College London, 86-96 Chenies Mews, London WC1E 6HX, UK 2. London Fertility Centre, Cozens House, 112a Harley Street, London W1G 7JH, UK |
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Citation | Glentis, S., Craft, I., Thornhill, A., Harper, J.C.: DNA microarray techniques review, Epitheorese Klin. Farmakol. Farmakokinet. 20(1): 5-11 (2006) | |
Publication Date | Accepted for publication (Final version): 15 April 2006 | |
Full Text Language | English | |
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Keywords | Microarray, CGH-arrays, molecular biology, biotechnology, genetic diagnosis. | |
Other Terms | review article | |
Summary | DNA microarray technology has the ability to determine and analyze thousands of genes simultaneously. This has led to microarrays being one of the most powerful tools in molecular biology which can be used in most areas of biology and medicine. Routine tests will be the next step for microarrays including prenatal and preimplantation genetic diagnosis, forensic sciences and pharmacogenomics. However, designing a microarray experiment is not easy. Different technologies and experimental approaches have been used from different companies concerning probes, platforms, fabrication, labelling, scanning and data analysis each with advantages and disadvantages. For accurate results, a designing experiment has to consider all these different methods and decide which approach would give robust results. | |
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