Τόμος 23 (2009) – Τεύχος 2 – Άρθρο 9 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 23 (2009) – Issue 2 – Article 9 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title The role of aldosterone in the pathophysiology of renal disease
Authors Thomas Mavrakanas and Maria Mironidou-Tzouveleki

A’ Laboratory of Pharmacology, Medical School, Aristotle University of Thessaloniki

Citation Mavrakanas, T., Mironidou-Tzouveleki, M.: The role of aldosterone in the pathophysiology of renal disease, Epitheorese Klin. Farmakol. Farmakokinet. 23(2): 99-101 (2009)
Publication Date Accepted for publication (Final Version): July 1, 2009
Full Text Language English
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Keywords Aldosterone, renal disease, proteinuria, spironolactone, eplerenone.
Other Terms review article
Summary Activation of the renin-angiotensin-aldosterone system (RAAS) deteriorates renal function in the case of chronic progressive renal disease. Aldosterone is now implicated as an important component of the RAAS system in renal tissue. Hyperaldosteronism is documented in clinical chronic renal insufficiency and aldosterone levels correlate with renal decay rate in diabetic patients. Targeted interruption of aldosterone action has been successful in reducing proteinuria in several animal models of renal disease as well as in small clinical trials. However, aldosterone blockade with spironolactone is limited by the prevalence of adverse effects. The increased selectivity of eplerenone allows for clinical efficacy without the unwanted side effects.
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