Τόμος 23 (2009) – Τεύχος 3 – Άρθρο 5 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 23 (2009) – Issue 3 – Article 5 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

By | | Άρθρο επισκόπησης - Review Article, Διαμαντής Κιάσσος - Diamantis Kiassos, Ε. Αγαπητός - E. Agapitos, Ε. Χατζηγιαννάκης - E. Chatzigiannakis, Πλήρες Κείμενο στα Αγγλικά - Full Text in English, Σ. Θεοχάρης - S. Theocharis, Σ. Παπαδόπουλος - S. Papadopoulos
Title Eversion of fulminant hepatic necrosis and encephalopathy with ammonium chloride
Authors D. Kiassos1, S. Papadopoulos1, E. Chatzigiannakis2, E. Agapitos2 and S. Theocharis2

1. Pathologic Anatomy Department, Medical School, University of Athens, Athens, Hellas

2. First Propaedeutic Clinic, Hippokrateion Hospital, Athens, Hellas
Citation Kiassos, D., Papadopoulos, S., Chatzigiannakis, E., Agapitos, E., Theocharis, S.: Eversion of fulminant hepatic necrosis and encephalopathy with ammonium chloride, Epitheorese Klin. Farmakol. Farmakokinet. 23(3): 139-142 (2009)
Publication Date Accepted for publication (Final Version): July 1, 2009
Full Text Language English
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Keywords Hepatic necrosis, encephalopathy, fulminant hepatic failure, acute hepatic failure, ammonium chloride.
Other Terms review article
Summary Thirty-two winstar rats were caused to hepatic necrosis and encephalopathy with 400 mg/kg TAA (hepatotoxin thioacetamide) in three consecutive time periods of 24 hours. The thirty-three rats were divided into four groups. Group I, control group to which placebo 0.9% NaCl was administered while to other groups 300 mg/kg per weight kg NaCl was administered (NH4Cl), 600 mg/kg weight of ammonium chloride (NH4Cl) and 900 mg/kg weight of ammonium chloride (NH4Cl) respectively. Group III which was administered 600 mg/kg weight of NaCl (NH4Cl) improved the biochemical, immune-biological and histological indexes and presented statistic grandness p<0.001 ANOVA TEST. Finally, it also reduced the hepatic encephalopathy with the same grandness.
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