Τόμος 24 (2010) – Τεύχος 1 – Άρθρο 6 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 24 (2010) – Issue 1 – Article 6 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Somatostatin receptor subtypes and their role in scintigraphy and targeted radiotherapy
Authors A. Zissimopoulos¹, N. Boussios¹, D. Tsairidis¹, E. Karathanos¹ and D. Matheos²

1. Nuclear Medicine Department and 2. Oncology Clinic, Democritus University of Thrace, Alexandroupolis, Hellas

Citation Zissimopoulos, A., Boussios, N., Tsairidis, D., Karathanos, E., Matheos, D.: Somatostatin receptor subtypes and their role in scintigraphy and targeted radiotherapy, Epitheorese Klin. Farmakol. Farmakokinet. 24(1): 35-40 (2010)
Publication Date Accepted for publication (Final Version): April 10, 2010
Full Text Language English
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Keywords Neuroendocrine tumors, somatostatin receptors, 111In-DTPA octreotide.
Other Terms review article
Summary Somatostatin peptide has multiple functions mediated by a family of G-protein coupled receptors. There are five known subtypes of the somatostatin receptors, termed SSTR1-5. The somatostatin receptors (SSTRs) are found in a variety of tumors, in particular in neuroendocrine tumors but also in non tumoral lesions such as sarcoidosis, rheumatoid arthritis ecc. Scintigraphy with somatostatin-analogs is very helpful in the detection of primary SSTR expressing tumors and their metastases. 111In-DTPA octreotide (octreoscan) is the most commonly used radiopharmaceutical and binds with high affinity to the sst2 receptor. Other SSTR imaging agents with a different sst affinity profile than octreotide are 99mTc-depreotide and 111In-DOTA lanreotide. Patients with positive SSTR imaging are candidates for therapy either with cold somatostatin analogs such as Lanreotide or radiotherapy using radiolabeled SS-analogs. For SSTR-targeted radiotherapy the use of the beta-radiation emitting compound 90Y-[DOTA]-DPhe1-Tyr3 (DOTATOC) appears extremely promising in tumors expressing SSTRs, with more than 25% remissions and about 50% disease stabilization.
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