| Title | The role of soluble triggering receptor on myeloid cells in patients with sepsis syndrome | |
| Authors | L. Leonidou¹, E. Giamarellos-Bourboulis², H.P. Bassaris¹ and C.A. Gogos¹
Departments of Medicine, 1. Patras University Medical School and 2. Athens University Medical School, Greece |
|
| Citation | Leonidou, L., Giamarellos-Bourboulis, E., Bassaris, H.P., Gogos, C.A.: The role of soluble triggering receptor on myeloid cells in patients with sepsis syndrome, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 100-101 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
|
| Keywords | Sepsis, strem-1, survival, infection. | |
| Other Terms | review article | |
| Summary | Objective: To investigate the concentrations of plasma levels of soluble (s)TREM-1 in patients with sepsis and evaluate their predictive value on outcome, in comparison to SOFA score. Blood was taken from 43 patients with sepsis severe sepsis. Plasma concentrations of sTREM-1 were determined within 24 hours after admission in hospital. All septic patients had detectable levels of sTREM-1. Non-survivors had slightly lower levels of sTREM-1 compared to survivors but without statistical difference. Patients with bacteremia had lower levels of sTREM-1 compared to those with no bacteremia, but again statistically not significant. No correlation was detected between sTREM-1 and the severity of sepsis (SOFA) or GRP. Logistic regression showed that SOFA was the only parameter independently associated with death. sTREM-1 seems to be a potential marker for the presence of sepsis but not a predictor of outcome, while SOFA score has a significant prognostic value. More studies should be designed to evaluate sTREM value as a clinical tool in sepsis. | |
| References | 1. Gibot S., Kolopp-Sarda M.N., Bene M.C., Bollaert P.E., Lozniewski A., Mory F., Levy B., Faure G.C.: A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J. Exp. Med. 200: 1419-1426 (2004)
2. Gibot S., Cravoisy A., Kolopp-Sarda M.N., Bene M.C., Faure G., Bollaert P.E., Levy B.: Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis. Crit. Care Med. 33: 792-796 (2005) 3. Gibot S., Cravoisy A.: Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin. Med. Res. 2(3): 181-187 (2004) 4. Routsi C., Giamarellos-Bourboulis E.J., Antonopoulou A., Kollias S., Siasiakou S., Koronaios A., Zakynthinos S., Armaganidis A., Giamarellou H., Roussos C.: Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock? Clin. Exp. Immunol. 142: 62-67 (2005) 5. Giamarellos-Bourboulis E.J., Zakynthinos S., Baziaka F., Papadomichelakis E., Virtzili S., Koutoukas P., Armaganidis A., Giamarellou H., Roussos C.: Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis. lntens. Care Med. 32: 237-243 (2006) 6. Bouchon A., Facchetti F., Welgand M.A., Colonna M.: TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410: 1103-1107 (2001) 7. Colonna M., Facchetti F.: TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses. J. lnfect. Dis. 187: (2003) |
|
| Relative Papers |
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2006 – ANNUAL SUBSCRIPTION 2006 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|