Τόμος 22 (2008) – Τεύχος 2 – Συμπλήρωμα 1 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 22 (2008) – Issue 2 – Supplement 1 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title The role of drug-protein binding in the current therapy
Authors Anastasia Alevizouand Antonia Kotsiou2

1. Dpt. of Cardiothoracic Anaesthesia and Intensive Care, James Cook University Hospital, Middlesbrough, UK

2. Pharmacy Dpt., Aretaieio University Hospital, Athens Greece

Citation Alevizou, A., Kotsiou, A.: The role of drug-protein binding in the current therapy, Epitheorese Klin. Farmakol. Farmakokinet. 22(3): 383-388 (2008)
Publication Date Accepted for publication (Final Version): 10 July 2008
Full Text Language English
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Keywords Drug-protein binding, albumin, tissues proteins, current therapy.
Other Terms Review article
Summary Drug transport and disposition in the organism are variable, depending on non-specific and reversible drug binding to plasma and tissues proteins Albumin possesses the key specific sites for acidic (1) and basic (2) drug binding and can interact with them in the plasma. However a1-acid glycoprotein and lipoproteins contribute significantly to this process. Furthermore, the binding of drugs to tissues is also non-specific and more importantly numerous molecules are involved in this pharmacokinetic procedure. Diseases and generally stress conditions induce conformational changes either in plasma or in tissue proteins. This may affect the binding of drugs in target molecules and may provoke significant pharmacokinetic alterations. For this reason the pharmacokinetic monitoring may be mandatory in cases, where drug-drug or drug-disease interactions are anticipated.   
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