| Title | Inhibitory activity on amyloid-β protein aggregation and antioxidant properties of blueberry extract | |
| Authors | Magdalini A. Papandreou¹, Spyros Efthimiopoulos², Paul Cordopatis³, Dorothy Klimis-Zacas⁴, Marigoula Margarity¹ and Fotini N. Lamari³
1. Laboratory of Human & Animal Physiology, Department of Biology, University of Patras, Greece 2. Division of Animal & Human Physiology, Department of Biology, University of Athens, Greece 3. Laboratory of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26500 Patras, Greece 4. Department of Food Science and Human Nutrition, University of Maine, Orono, ME 04469, USA |
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| Citation | Papandreou, M.A., Efthimiopoulos, S., Cordopatis, P., Klimis-Zacas, D., Margarity, M. et al: Inhibitory activity on amyloid-β protein aggregation and antioxidant properties of blueberry extract, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 105-107 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Alzheimer’s disease, fibrillogenesis, anthocyanins, vaccinium angustifolium, blueberries. | |
| Other Terms | review article | |
| Summary | The purpose of this study was to examine, the antioxidant properties of anthocyanins from Vaccinium angustifolium wild fruits (blueberries) and their in vitro effect on Aβ1-40 aggregation. The antioxidant properties of the anthocyanin-rich blueberry extract were determined by ferric-reducing antioxidant power and trolox-equivalent antioxidant capacity, while its effect on Aβ aggregation was studied by a thioflavine T-based fluorescence assay and by agarose gel electrophoresis. Results showed that the extract not only possesses high antioxidant properties, but also exhibited a significant inhibition of Aβ aggregation (up to 70% at the concentration of 15 µg/mL). Our findings suggest the possible use of V. angustifolium anthocyanins for inhibition of aggregation and deposition of Aβ in the human brain. | |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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