| Title | Patterns of human interleukin-8 (IL-8) gene expression during growth related changes and hemin-induced differentiation in K562 CML cells | |
| Authors | Sofia Georgiou and Asterios S. Tsiftsoglou
Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Aristotle University, Thessaloniki, Greece |
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| Citation | Georgiou, S., Tsiftsoglou, A.S.: Patterns of human interleukin-8 (IL-8) gene expression during growth related changes and hemin-induced differentiation in K562 CML cells, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 95-97 (2010) | |
| Publication Date | 2010 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Interleukin-8, K562 cells, hemin, mRNA levels. | |
| Other Terms | Review article | |
| Summary | IL-8, a pro-inflammatory cytokine, is produced from a variety of cancer cells and it was found to contribute to a more aggressive attitude of cancer cells. In the present study, we have found that K562 cells produce some basal levels of IL-8 mRNA, which are increased by several folds by hemin. The mechanism that contributes to this increase is found to be highly and rapidly-responsive. The biological significance of IL-8 production for the progression of leukeamia is being proposed. | |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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