| Title | Possible protective effect of 2,3-dihydro-2H-1,4-benzoxazine derivatives in a prion disease model | |
| Authors | Fani Koukouli1, Evgenia Salta1, Theodora Calogeropoulou2 and Theodoros Sklaviadis1
1. Department of Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece 2. National Hellenic Research Foundation, Institute of Organic and Pharmaceutical Chemistry, Athens, Greece |
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| Citation | Koukouli, F., Salta, E., Calogeropoulou, T., Sklaviadis, T.: Possible protective effect of 2,3-dihydro-2H-1,4-benzoxazine derivatives in a prion disease model, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 99-101 (2010) | |
| Publication Date | 2010 | |
| Full Text Language | English | |
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| Keywords | Transmissible spongiform encephalopathies, prion protein, benzoxazines, drug screening. | |
| Other Terms | Review article | |
| Summary | Prion diseases are fatal neurodegenerative disorders characterized by the structural conversion of a normal, cellular protein, PrPC, into an aberrant isoform, termed PrPSc. The physiological function of PrPC has remained enigmatic, although there is evidence that PrPC may play a role in protecting cells from oxidative stress, which, per se, has been implicated in prion pathogenesis. Benzoxazines are bicyclic heterocyclic compounds with several pharmaceutically important properties, including neuroprotection and antioxidation. In this study, a series of novel benzoxazine derivatives was evaluated in vitro regarding their effect on the levels of both the physiological PrPC and the abnormal PrPSc. A possible involvement in the inhibition of neuronal cell death, would render these compounds valuable neuroprotective agents. Moreover, our in vitro system could serve as a particularly useful model in further screening assays. | |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2010 – ANNUAL SUBSCRIPTION 2010 | |
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