| Title | Acetaminophen modulates the oxidative stress response in eucaryotic cells | |
| Authors | E.Ch. Yiannakopoulou and E. Tiligada
Department of Pharmacology, Medical School, University of Athens, Athens, Greece |
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| Citation | Yiannakopoulou, E.Ch., Tiligada, E.: Acetaminophen modulates the oxidative stress response in eucaryotic cells, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 125-127 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Acetaminophen, cellular stress, oxidative stress, pro-oxidants, anti-oxidants, preconditioning, yeast. | |
| Other Terms | review article | |
| Summary | Yeast cells exposed to adverse conditions employ a number of defense mechanisms in order to respond efficiently to stress. Stress response can be modulated by a number of pharmacological agents such as acetaminophen. The analgesic and antipyretic actions of acetaminophen are well known for over 100 years. How- ever its precise mechanism of action remains a matter of investigation and recently there is growing interest in many of the novel actions of this drug. Acetaminophen being a phenol has both pro-oxidant and anti-oxidant actions confering protection under conditions of cellular stress. This study investigated the modulation of the cellular stress response by acetaminophen under oxidative stress conditions. The unicellular eukaryotic organism Saccharomyces cerevisiae characterized by a highly conserved stress response was used as the experimental model. The preliminary results showed a tendency towards increased cell survival after preconditioning with high doses of acetaminophen, implying that acetaminophen might act as an inducer of adaptive mechanisms. | |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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