| Title | Pharmacodynamic interaction of norfloxacin and theophylline with peripheral GABAA-Receptors | ||
| Authors | Georgios A. Delis, Efstathios Nikolaidis, Theophano A. Psarra, Georgios C. Batzias and Maria Koutsoviti-Papadopoulou
Laboratory of Pharmacology, Veterinary Faculty, Aristotle University, Thessaloniki, Greece |
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| Citation | Delis, G., Nikolaidis, E., Psarra, T.A., Batzias, G.C., Koutsoviti-Papadopoulou, M.: Pharmacodynamic interaction of norfloxacin and theophylline with peripheral GABAA-Receptors, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 134-137 (2010) | ||
| Publication Date | 2010 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | GABAA, theophylline, norfloxacin, pharmacodynamic interaction, guinea pig ileum. | ||
| Other Terms | Review article | ||
| Summary | The present study investigates the effects of the fluoroquinolone norfloxacin, the methyl-xanthine theophylline, as well as of the combined norfloxacin-theophylline application on the responses of the guinea pig ileum to the inhibitory neurotransmitter γ-aminobutyric acid (GABAA). According to the results, GABAA (from 1.6×10-6 up to 10-3 M) causes transient contraction in the guinea pig ileum preparations with a pEC50 value of 5.04, followed by relaxation. Norfloxacin, at concentrations equal or higher than 10-5 M, and theophylline, at concentrations equal or higher than 3×10-4 M, inhibited the contractile responses of the ileum to GABAA, without modifying its relaxing effect, whereas lower norfloxacin and theophylline levels were required to cause a similar degree of inhibition when the above drugs were combined. In conclusion, the inhibitory effect of either norfloxacin or theophylline on the contractile response of the guinea pig ileum to GABAA is enhanced when the two drugs are combined. This amplification could be attributed to the pharmacodynamic interaction of norfloxacin and theophylline at the level of GABAA-receptors. | ||
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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