Τόμος 24 (2010) – Τεύχος 2 – Άρθρο 64 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 24 (2010) – Issue 2 – Article 64 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Regulation of aromatase expression by hormones, drugs pesticides and environmental pollutants in canine mammary CMT-U27 cells
Authors Savvas K. Mavridis and Ioannis S. Pappas

Laboratory of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Thessaly, Karditsa, Greece

Citation Mavridis, S.K., Pappas, I.S.: Regulation of aromatase expression by hormones, drugs pesticides and environmental pollutants in canine mammary CMT-U27 cells, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 171-174 (2010)
Publication Date 2010
Full Text Language English
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Keywords Aromatase, breast cancer, regulation, inducers, inhibitors.
Other Terms Review article
Summary Aromatase, the enzyme that coverts testosterone to 17β-estradiol, has attracted attention lately because of its involvement in some forms of breast cancer in women. Studies are now undergoing on a variety of species to elucidate the effect of various agents on aromatase expression. Dog is an important species, widely used by the pharmaceutical industry for many study types, including those that will impact decision on drug development. In the present study, a wide variety of agents, including steroid hormones, drugs, pesticides, and environmental pollutants, were used to investigate their effect on aromatase expression in the canine mammary CMT-U27 cell line using quantitative real-time polymerase chain reaction (qPCR) on DNA synthesized from RNA extracted from the cells.
References 1. Katsiabas D.S., Mavridis S.K., Pappas I.S.: Expression of Cytochrome P450s and Transctiption Factors Pxr and Car in Canine Tissues. Rev. Clin. Pharmacol. And Pharmacokinetics, 22: 189-192 (2008)

2. Bretveld R.W., Thomas C.M.G., Scheepers P.T.J., Zielhuis G.A., Roeleveld N.: Pesticide exposure: the hormonal function of the female reproductive system disrupted? Reprod. Biol. Endocrinol. 4: 30-58 (2006)

3. Simpson E.R., Zhao Y., Agarwal V.R., Michael M.D., Bulun S.E., Hinshelwood M.M., Graham-Lorence S., Sun T., Fisher C.R., Qin K., Mendelson M.D.: Aromatase expression in health and disease: Recent Prog. Horm. Res. 52: 185-213 (1997)

4. Diaz-Cruz E.S., Shpiro C.L., Brueggemeier R.W.: Cy-clooxygenase inhibitors suppress aromatase expression and activity in breast cancer cells. J. Clin. Endocrinol. Metab. 90: 2563-2570 (2005)

5. Hiscox S., Davies E.L., Barrett-Lee P., Aromatase inhibitors in breast cancer. Maturitas. 63: 275-279 (2009)

6. Hardy D.B., Janowski B.A., Chen C-C., and Mendelson C.R.: Progesterone Receptor Inhibits Aromatase and Inflammatory Response Pathways in Breast Cancer Cells via Ligand-Dependent and Ligand-Independent Mechanisms. Mol. Endocrinol. 22: 1812–1824 (2008)

7. Srinivasan R., Karundevi B.: Corticosterone Induces Steroidogenic Lesion in Cultured Adult Rat Leydig Cells by Reducing the Expression of StAR Protein and Steroidogenic Enzymes. J. Cell. Biochem. 103: 1472-1487 (2008)

8. Watanabe M., Ohno S., Nakajin S.: Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Eur. J. Endocrinol. 152: 619-624 (2005)

9. Yanase T., Mu Y-M., Nishi Y., Goto K., Nomura M., Okabe T., Takayanagi R., Nawata H.: Regulation of aromatase by nuclear receptors. J, Steroid Biochem. & Mol. Biol. 79: 187–192 (2008)

10. Watanabe M., Mariko Noda M., Nakajin S.: Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells. J. Endocrinol. 188: 59–68 (2006)

11. Kopelovich L., Fay J.R., Sigman C.C., Crowell J.A.: The Mammalian Target of Rapamycin Pathway as a Potential Target for Cancer Chemoprevention. Cancer Epidemiol. Biomarkers Prev. 16: 1330-40 (2007)

12. Davies G., L.-A. Martin L.-A., N. Sacks N., Dowsett M.: Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention. Ann. Oncol. 13: 669–678 (2002)

13. Kim J.I., Han E.H., Kim H.G., Oh K.N, Kim S.K., Lee K.Y., Jeong H.G.: Bisphenol A-induced aromatase activation is mediated by cyclooxygenase-2 upregulation in rat testicular Leydig cells. Toxicol. Lett. 193: 200–208 (2010)

14. Talbert D.R., Allred C.D., Zaytseva Y.Y., Kilgore M.W.: Transactivation of ERa by Rosiglitazone induces proliferation in breast cancer cells. Breast Cancer Res. Treat. 108: 23–33 (2008)

15. Yeb L., Chanb M.Y., Leung L.K.: The soy isoflavone genistein induces estrogen synthesis in an extragonadal pathway. Mol. Cell. Endocrinol. 302: 73-80 (2009)

16. Qiao Y., Jinyan Cao J., Liangqun Xie L., and Xiaolin Shi X.: Cell Growth Inhibition and Gene Expression Regulation by (-)-Epigallocatechin-3-Gallate in Human Cervical Cancer Cells. Arch. Pharm. Res. 32: 1309-1315 (2009)

17. Sun M., Estrov Z., Ji Y., Coombes K.R., Harris D.H., Kurzrock R.: Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol. Cancer Ther. 7:  464 (2008)

18. Rice S., Pellatt L., Ramanathan K., Whitehead S.A., Mason H.D.: Metformin inhibits aromatase via an ERK (extracellular signal-regulated kinase) – mediated pathway. Endocrinol. 150: 4794–4801 (2009)

19. Sanderson J.T., Hordijk J., Denison M.S., Springsteel M.F., Nantz M.H., van den Berg M.: Induction and Inhibition of Aromatase (CYP19) Activity by Natural and Synthetic Flavonoid Compounds in H295R Human Adrenocortical Carcinoma Cells. Toxicol. Sci. 82: 70–79 (2004)

20. Deb S., Zhou J., Amin S.A., Imir A.G., Yilmaz M.B., Lin Z., Bulun S.E.: A Novel Role of Sodium Butyrate in the Regulation of Cancer-associated Aromatase promoters I and II by Disrupting a Transcriptional Complex in Breast Adipose Fibroblasts. J. Biol. Chem. 281: 2585–2597 (2006)

21. Wong J.Y.Y, Huggins G.S., Debidda M., Munshi N.C., De Vivo I.: Dichloroacetate Induces Apoptosis in Endometrial Cancer Cells. Gynecol. Oncol. 109: 394–402 (2008)

22. Sanderson J.T., Boerma J., Lansbergen G.W.A., van den Berg M.: Induction and Inhibition of Aromatase (CYP19) Activity by Various Classes of Pesticides in H295R Human Adrenocortical Carcinoma Cells. Toxicol. Appl. Pharmacol. 182: 44–54, (2002)

23. Andersen H.R., Vinggaard A.M., Rasmussen T.H., Gjermandsen I.M., Bonefeld-Jørgensen E.C.: Effects of Currently Used Pesticides in Assays for Estrogenicity, Androgenicity, and Aromatase Activity in Vitro. Toxicol. Appl. Pharmacol. 179: 1–12 (2002)

24. Fan W., Yanase T., Morinaga H., Gondo S., Okabe T., Nomura M., Komatsu T., Morohashi K.I., Hayes T.B., Takayanagi R., Nawata H.: Atrazine-Induced Aromatase Expression Is SF-1 Dependent: Implications for Endocrine Disruption in Wildlife and Reproductive Cancers in Humans. Environ Health Perspect. 115: 720–727 (2007)

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