| Title | Safety/tolerability of α2δ ligand pregabalin in the treatment of fibromyalgia: an evidence based evaluation | ||
| Authors | Georgios Papazisis1, Thrasivoulos Tzellos1, Konstantinos Toulis2, Dimitrios Goulis2, Chrysanthi Sardeli1, Michael Chourdakis1 and Dimitrios Kouvelas1
1. 2nd Department of Pharmacology and Papageorgiou Hospital, School of Medicine, Aristotle University, Thessaloniki, Greece |
||
| Citation | Papazisis, G., Tzellos, T., Toulis, K., Goulis, D., Sardeli, C. et al.: Safety/tolerability of α2δ ligand pregabalin in the treatment of fibromyalgia: an evidence based evaluation, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 193-194 (2010) | ||
| Publication Date | 2010 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
||
| Keywords | Pregabalin, fibromyalgia, safety, tolerability, meta-analysis. | ||
| Other Terms | Review article | ||
| Summary | α2δ ligands gabapentin and pregabalin are approved for the treatment of pain from diabetic neuropathy and post-herpetic neuralgia in adults and as adjunctive therapy of partial seizures in children and pregabalin has been also approved for treatment of anxiety disorders. Fibromyalgia (FBM) is a common chronic pain disorder affecting up to 2% of the general population. Aim of our study was to estimate the safety and the tolerability of pregabalin in the treatment of fibromyalgia and for that purpose a systematic review of relevant randomized double-blind placebo-controlled trials was performed. | ||
| References | 1. Tzellos T., Toulis K., Goulis D., Papazisis G., Zampeli V., Vakfari A., Kouvelas D.: Gabapentin and pregabalin in the treatment of fibromyalgia: a systematic review and a meta-analysis. J. Clin. Pharm. Ther. 2010. In press.
2. Tzellos T.G., Papazisis G., Toulis K.A., Sardeli C., Kouvelas D.: A2δ ligands gabapentin and pregabalin: future implications in daily clinical practice. Hippokratia 2010. In press. 3. Tzellos T.G., Papazisis G., Amaniti E., Kouvelas D.: Efficacy of pregabalin and gabapentin for neuropathic pain in spinal-cord injury: an evidence-based evaluation of the literature. Eur. J. Clin. Pharmacol. 64: 851-858 (2008) 4. Toulis K.A., Tzellos T., Kouvelas D., Goulis D.G.: Gabapentin for the treatment of hot flashes in women with natural or tamoxifen-induced menopause: a systematic review and meta-analysis. Clin. Ther. 31: 221-235 (2009) 5. Crofford L.J., Rowbotham M.C., Mease P.J., et al.: Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 52: 1264-1273 (2005) 6. Mease P.J., Russell I.J., Arnold L.M., Florian H., Young J.P.,Jr, Martin S.A., Sharma U. A randomized, double-blind, placebo-controlled, phase III trial of pregabalin in the treatment of patients with fibromyalgia. J. Rheumatol. 35: 502-514 (2008) 7. Arnold L.M., Russell I.J., Diri E.W., et al.: A 14-week, randomized, double-blinded, placebo-controlled monotherapy trial of pregabalin in patients with fibromyalgia. J. Pain 9: 792-805 (2008) |
||
| Relative Papers | |||
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2010 – ANNUAL SUBSCRIPTION 2010 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|