| Title | Cadmium effects on the expression of inflammatory and angiogenic mediators of skeletal muscles after sustained ischaemia/reperfusion injury | ||
| Authors | D.G. Parthenis2, P. Zaharatos2, E. Pantikidou3, ST. Theoharis2, TH. Vassilakopoulos3, H. Carageorgiou1, CH. Klonaris2 and G. Kouraklis2
1. Pharmacology Department, Medical School, Athens University, Athens, Greece 2. B Propaedeutic Surgery Clinic of Laikon hospital, Athens University, Athens, Greece 3. Experimental Surgery Unit, Evangelismos Hospital, Athens University, Athens, Greece |
||
| Citation | Parthenis, D.G., Zaharatos, P., Pantikidou, E., Theoharis, S., Vassilakopoulos, T. et al.: Cadmium effects on the expression of inflammatory and angiogenic mediators of skeletal muscles after sustained ischaemia/reperfusion injury, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 195-199 (2010) | ||
| Publication Date | 2010 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
||
| Keywords | Rat peripheral skeletal muscles, Cd, ischaemia-reperfusion injury, interleukins, angiogenic mediators. | ||
| Other Terms | Review article | ||
| Summary | Cadmium (Cd) is a very toxic metal affecting almost every organ of the body. Due to its increasing presence in the environment, food and tobacco smoking has been attracted much attention. As Cd antagonizes Ca in cell metabolism it is considered as a xenobiotic implicated in the pathophysiology of cardiovascular disease (hypertension, atherosclerosis, and peripheral arterial disease (PAD). The present study is the first one that was conducted in a rat model of unilateral limb ischaemia where inflammatory or angiogenic mediators were measured post hypoxic stimuli, in peripheral skeletal muscle extracts. It was hypothesized that hypoxic stimuli such as ischaemia reperfusion injury with/without either acute or chronic cadmiosis alters the profile of proinflammatory cytokines (interleukins IL-6, IL-1b) derived from peripheral skeletal muscles. It was also hypothesized that inflammatory molecules such as m-RNA IL-6 or angiogenic mediators such as m-RNA VEGF or m-RNA Ang-2 will be influenced by acute or chronic Cd exposure. The results indicate that Cd in acute or chronic exposure of rat skeletal muscles increases the expression of the inflammatory mediators m-RNA IL-6, IL-6, IL-1b proteins, following hypoxic stimuli. In addition a decrease of the angiogenic mediators m-RNA VEGF and m-RNA Ang-2 was observed in the same muscle extracts, where their expression is considered part of the adaptation response to hypoxia. Therefore it may be of clinical interest to understand the molecular mechanisms by which smoking causes vascular disease or to link specific constituents of tobacco smoke such as Cd to individual manifestations of cardiovascular toxicity. | ||
| References | 1. Carageorgiou H., Liapi C., Messari I., Tyligada C., Papadopoulos G., Sitaras N.: Environmental Pharmacology. University of Athens, Athens, pp. 195-200, 2004
2. Tzotzes V., Tzilalis V., Giannakakis S., Saranteas T., Papas A., Mourouzis I., Mourouzis C., Zarros A., Pantos C., Cokkinos D., Carageorgiou H.: Effects of acute and chronic cadmium administration on the vascular reactivity of rat aorta. Biometals 20: 83-91 (2007) 3. Satarug S., Garrett S.H., Sens M.A., Sens D.A.: Cadmium, environmental exposure, and health outcomes. Environ. Health Perspect. 118: 182-90 (2010) 4. Sutoo D., Akiyama K.: Effect of cadmium or magnesium on calcium-dependent central function that reduces blood pressure. Arch. Toxicol. 74: 1-4 (2000) 5. Kuester R.K., Waalkes M.P., Goering P.L., Fisher B.L., McCuskey R.S., Sipes I.G.: Differential hepatotoxicity induced by cadmium in Fischer 344 and Sprague-Dawley rats. Toxicol. Sci. 65:151-159 (2002) 6. Nolan C.V., Shaikh Z.A.: The vascular endothelium as a target tissue in acute cadmium toxicity. Rev. Life Sci. 20: 1403-1409 (1986) 7. Bhatnagar A.: Environmental cardiology: studying mechanistic links between pollution and heart disease. Rev. Circ Res. 29;99: 692-705 (2006) 7. Bhatnagar A.: Environmental cardiology: studying mechanistic links between pollution and heart disease. Rev. Circ Res. 29;99: 692-705 (2006) 8. Revis N.W., Zinsmeister A.R., Bull R.: Atherosclerosis and hypertension induction by lead and cadmium ions: an effect prevented by calcium ion. Proc. Natl. Acad. Sci. USA 78: 6494-6498 (1981) 9. Houston M.C.: The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction. Altern. Ther. Health Med. 13: S128-133 (2007) 10. Järup L., Akesson A.: Current status of cadmium as an environmental health problem. Rev. Toxicol. Appl. Pharmacol. 238: 201-208 (2009) 11. Navas-Acien A.: Lead, cadmium, smoking, and in-creased risk of peripheral arterial disease. Circulation 109: 3196-3201 (2004) 12. Ognjanović B.I., Pavlović S.Z., Maletić S.D., Zikić R.V., Stajn A.S., Radojicić R.M., Saicić Z.S., Petrović V.M.: Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium. Physiol. Res. 52: 563-570 (2003) 13. Li C.: Reactive species mechanisms of cellular hypoxia – reoxygenation injury. Am. J. Physiol. Cell. Physiol. 282: C227-C241 (2002) 14. Atahan E., Ergün Y., Kurutaş E.B., Alıcı T.: Protective Effect of zinc aspartate on long-term ischemia-reperfusion injury in rat skeletal muscle. Biol. Trace Elem. Res.: (2009) 15. Shaikh Z.A., Vu T.T., Zaman K.: Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol. Appl. Pharmacol. 154: 256-263 (1999) 16. Richardson R.S., Wagner H., Mudaliar S.R., Henry R., Noyszewski E.A., Wagner P.D.: Human VEGF gene expression in skeletal muscle: effect of acute normoxic and hypoxic exercise. Am. J. Physiol. 277: H2247-2252 (1999 ) 17. Takihara-Yammauchi K.: Hypoxic stress induces cardiac myocyte-derived interleukin-6. Circulation 91: 1520-1524 (1995) 18. Zachary Ian.: Vascular endothelial growth factor and anti-angiogenic peptides as therapeutic and investigational molecules. Rev. Drugs 6: 224-231 (2003) 19. Balharry D., Sexton K., BéruBé K.A.: An in vitro approach to assess the toxicity of inhaled tobacco smoke components: nicotine, cadmium, formaldehyde and ure-thane. Toxicology 244: 66-76 (2008) 20. Dong W., Simeonova P.P., Gallucci R., Matheson J., Flood L., Wang S., Hubbs A., Luster M.I.: Toxic metals stimulate inflammatory cytokines in hepatocytes through oxidative stress mechanisms. Toxicol. Appl. Pharmacol. 151: 359-366 (1998) 21. Ikonomidis I., Athanassopoulos G., Lekakis J., Venetsanou K., Marinou M., Stamatelopoulos K., Cokkinos D.V., Nihoyannopoulos P.: Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: a dobutamine stress echocardiography study. Circulation 112: 3272-3279 (2005) 22. Qin S.L., Li T.S., Kubo M., Ohshima M., Furutani A., Hamano K.: Transient increase of cytokines in the acute ischemic tissue is beneficial to cell-based therapeutic angiogenesis. Circ. J. 72: 2075-2080 (2008) 23. Scholz D., Cai W.J., Schaper W.: Arteriogenesis, a new concept of vascular adaptation in occlusive disease. Review. Angiogenesis 4: 247-257 (2001) 24. Namba T., Koike H., Murakami K., Aoki M., Makino H., Hashiya N., Ogihara T., Kaneda Y., Kohno M., Morishita R.: Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model. Circulation 108: 2250-2277 (2003) 25. Tressel S.L., Kim H., Ni C.W., Chang K., Velasquez-Castano J.C., Taylor W.R., Yoon Y.S., Jo H.: Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis. Arterioscler. Thromb. Vasc. Biol. 28: 1989-1995 (2008) 26. Gustafsson T., Rundqvist H., Norrbom J., Rullman E., Jansson E., Sundberg C.J.: The influence of physical training on the angiopoietin and VEGF-A systems in human skeletal muscle. J. Appl. Physiol. 103: 1012-1020 (2007) |
||
| Relative Papers | |||
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2010 – ANNUAL SUBSCRIPTION 2010 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|