| Title | Nitric oxide levels in the dental pulp of streptozocin induced diabetic rats | ||
| Authors | Efrosyne Tsirella1, Constantinos Tomos1, Stergios Tsartsalis1, Konstantinos Kallaras2, Basile Kokkas1 and Maria Mironidou-Tzouveleki1
1. 1st Laboratory of Pharmacology and 2. Laboratory of Experimental Physiology, Medical School, Aristotle University, Thessaloniki, Greece |
||
| Citation | Tsirella, E., Tomos, C., Tsartsalis, S., Kallaras, K., Kokkas, B. et al.: Nitric oxide levels in the dental pulp of streptozocin induced diabetic rats, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 218-220 (2010) | ||
| Publication Date | 2010 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
||
| Keywords | Diabetes, dental pulp, pioglitazone, nitric oxide, streptozocin. | ||
| Other Terms | Review article | ||
| Summary | This study’s purpose is to determine nitric oxide (NO) concentration in the dental pulp of streptozocin induced diabetic rats and to identify whether pioglitazone administration affects NO levels in the dental pulp of normoglycaemic and diabetic rats. Wistar rats were divided into four groups: N, non-diabetic controls; NP, non-diabetic rats receiving pioglitazone (3 mg/kg); DM, streptozocin treated diabetic rats (50 mg/kg); and DM+P, diabetic rats receiving pioglitazone (3 mg/kg) for 8 weeks. Nitric oxide concentration was higher in the dental pulp of diabetic rats (527 ± 23 μM) than in control rats (177 ± 2 μM) (p < 0.001). Pioglitazone treated diabetic rats did not exhibit further increase in NO levels (542 ± 13 μM) (p = 0.315 versus DM group). Treatment with pioglitazone also did not affect NO levels in non-diabetic rats (162 ± 6 μM) (p = 0.35 versus N group). In conclusion, diabetes induced vascular changes in the dental pulp may be mediated by an increase in NO levels. Pioglitazone administration does not affect NO concentration either in normoglycaemic or in diabetic rats. | ||
| References | 1. Di Nardo Di Maio F., Lohinai Z., D’Arcangelo C., Esposito De Fazio P., Speranza L., De Lutiis A., Patruno A., Grilli A., Felaco M.: Nitric oxide synthase in healthy and inflamed human dental pulp. J. Dent. Res. 83: 312-316 (2004)
2. Kubes P., Suzuki M., Granger D.N.: Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci USA 88: 4651-4655 (1991) 3. Nathan C.: Nitric oxide as a secretory product of mammalian cells. FASEB J. 6: 3051-3064 (1992) 4. Lohinai Z., Szabó C.: Role of nitric oxide in physiology and pathophysiology of periodontal tissues. Med. Sci. Monit. 4: 1089-1095 (1998) 5. Lohinai Z., Balla I., Marczis J., Vass Z., Kovách A.G.: Evidence for the role of nitric oxide in the circulation of the dental pulp. J. Dent. Res. 74: 1501-1506 (1995) 6. Russell B.G.: The dental pulp in diabetes mellitus. Acta Pathol. Microbiol. Scand. 70: 319-320 (1967) 7. Bissada N.F., Sharawy A.M.: Histologic study of gingival and pulpal vascular changes in human diabetics. Egypt. Dent. J. 16: 283-296 (1970) 8. Sharma S.P.: Nitric oxide and the kidney. Indian. J. Nephrol. 14: 77-84 (2004) 9. Ishibashi M., Egashira K., Hiasa K., Inoue S., Ni W., Zhao Q., Usui M., Kitamoto S., Ichiki T., Takeshita A.: Antiinflammatory and antiarteriosclerotic effects of pioglitazone. Hypertension 40: 687-693 (2002) 10. Yoshimoto T., Naruse M., Nishikawa M., Naruse K., Tanabe A., Seki T., Imaki T., Demura R., Aikawa E., Demura H.: Antihypertensive and vasculo- and renoprotective effects of pioglitazone in genetically obese diabetic rats. Am. J. Physiol. 272: E989-996 (1997) 11. Davila-Esqueda M.E., Vertiz-Hernandez A.A., Martinez-Morales F.: Comparative analysis of the renoprotective effects of pentoxifylline and vitamin E on streptozotocin-induced diabetes mellitus. Ren. Fail. 27: 115-122 (2005) |
||
| Relative Papers | |||
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2010 – ANNUAL SUBSCRIPTION 2010 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|