| Title | Differential gene expression of versican isoforms in a hypoxic-ischemic rat brain model of perinatal asphyxia | ||
| Authors | Georgia Vassiliou¹, Thrasivoulos Tzellos², Evangelia Spandou³ and Aristidis Kritis¹
1. Lab of Physiology, 2. Lab of Pharmacology, 3. Lab of Experimental Physiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece |
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| Citation | Vassiliou, G., Tzellos, T., Spandou, E., Kritis, A.: Differential gene expression of versican isoforms in a hypoxic-ischemic rat brain model of perinatal asphyxia, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 221-223 (2010) | ||
| Publication Date | 2010 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Proteoglycan, versican, perinatal asphyxia, Wistar rat. | ||
| Other Terms | Review article | ||
| Introduction | Hypoxia-ischemia is a stressful condition for the organism and particularly for the nervous sys-tem. Immature brain is frequently exposed to combined hypoxic and ischemic insults during the perinatal period (1). Central nervous system response to hypoxia-ischemia is highly deter-mined by molecules of the extracellular matrix (ECM). Extracellular matrix molecules act as a physical framework and exert profound effects on cell shape and behavior including cell adhesion, spreading, migration, proliferation and differentiation (2). The major components of ECM are proteoglycans, glycosaminoglycans and collagens. Lecticans is a subfamily of chondroitin sulfate proteoglycans (CSPGs) that include aggrecan, neurocan, brevican and versican (3). Versican is one of the major extracellular proteoglycans in the developing and adult brain (4). In the present study we tried to evaluate Versican isoforms 0, 1, 2 and 3 gene expression in the recovering hypoxic-ischemic rat brain. | ||
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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