| Title | Genotoxic and cytostatic effect of atypical antipsychotic drugs in normal human lymphocytes cultures | ||
| Authors | Z. Iakovidou-Kritsi, K. Akritopoulou, M.T. Ekonomopoulou, T. Lialiaris, D. Mourelatos and E. Mioglou-Kalouptsi
Laboratory of General Biology and Genetics, Medical School, Aristotle University, Thessaloniki, Greece |
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| Citation | Iakovidou-Kiritsi, Z., Akritopoulou, Z., Ekonomopoulou, M.T., Lialiaris, T., Mourelatos, D. et al.: Genotoxic and cytostatic effect of atypical antipsychotic drugs in normal human lymphocytes cultures, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 166-168 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
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| Keywords | Clozapine, risperidone, olanzapine, cytotoxicity, proliferation rate index (PRI), sister chromatid exchange (SCE). | ||
| Other Terms | Review article | ||
| Summary | Antipsychotic medication has been used widely over the past decades for the control of psychiatric, developmental, eating and disruptive behavioural disorders. After the introduction of the typical antipsychotics in the 50s, new or atypical antipsychotics (including clozapine [CZP], risperidone [RSD] and olanzapine [OZP) have been increasingly used, in order to enhance antipsychotic activity and reduce side effects. Atypical antipsychotic drugs also possess serious adverse effects. As their cytogenetic activity is almost yet unknown, this investigation evaluates the effect of CZP, RSD and OZP on the SCE (Sister Chromatid Exchange) frequency and the PRI (Proliferation Rate Index) values in peripheral blood lymphocytes of healthy donors. SCEs and PRI are proved to be very sensitive indicators of genotoxicity and cytostaticity respectively. Our results indicate that CZP possesses significant genotoxic and cytostatic activity, whereas RSD and OZP have only cytotoxic activity. | ||
| References | 1. DuBois D.: Toxicology and overdose of atypical antipsychotic medications in children: does newer necessarily mean safer? Curr. Opin. Pediatr. 17: 227-233 (2005)
2. Findling R.L., McNamara N.K.: Atypical antipsychotics in the treatment of children and adolescents: clinical applications. J. Clin. Psychiatry 65: 30-44 (2004) 3. Del Bello M., Grcevich S.: Phenomenology and epidemiology of childhood psychiatric disorders that may necessitate treatment with atypical antipsychotics. J. Clin. Psychiatry 65(suppl 6): 12-19 (2004) 4. Reminghton: The science and practice of pharmacy. 21st edition 1509-1516 5. Freedman R.: Schizophrenia. A good review of the pathophysiology of schizophrenia and its treatments. N. Engl. J. Med. 349: 1738-1749 (2003) 6. Lialiaris T., Pantazaki A., Sivridis E., Mourelatos D.: Chlorpromazine-induced damage on nucleic acids: a combined cytogenetic and biochemical study. Mutat. Res. 265: 155-163 (1992) 7. Pantazaki A.A., Lialiaris T.S.: A combined biochemical and cytogenetic study of thioridazine-induced damage to nucleic acids. Mutagenesis 14: 243-248 (1999) 8. Mourelatos D.: Chromosome study as predictor of chemoresponse of tumours. Cancer J. 9: 136-141 (1996) 9. Goto K., Maeda S., Kano Y., Sugiyaama T.: Factors involved in differential Giemsa staining of Sister Chromatides. Chromosoma 66: 351-359 (1978) 10. Shin S.Y., Choi B.H., Ko J., Kim S.H., Kim Y.S., Lee Y.H.: Clozapine, a neuroleptic agent, inhibits Akt by counteracting Ca2+/calmodulin in PTEN-negative U-87MG human glioblastoma cells. Cell Signal. 18: 1876-86 (2006) 11. Fehsel K., Loeffler S., Krieger K., Henning U., Agelink M., Kolb-Bachofen V., Klimke A.: Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients. J. Clin. Psychopharmacol. 25: 419-426 (2005) 12. Leal Garza C.H., Valenciano Cedillo G.G., Rojas Alvarado M.A., Cortes Gutierrez E.I.: Mutagenic activity of diazepam evaluated by in vivo cytogenetic tests. Arch. Med. Res. 29: 285-9 (1998) |
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| Relative Papers | |||
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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