| Title | The role of polymorphisms in 5-HT2c receptor gene in type 2 diabetes mellitus and obesity in the Caucasian population | ||
| Authors | M. Iordanidou1, A. Tavridou1, M.V. Vasseiliadis2, K.I. Arvanitidis1, J. Petridis1, D. Christakidis2 and V.G Manolopoulos1
1Laboratory of Pharmacology and Clinical Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece 2Outpatient Diabetic Medical Clinic, Department of Internal Medicine, Alexandroupolis, Thrace, Greece |
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| Citation | Iordanidou, M., Tavridou, A., Vasseiliadis, M.V., Arvanitidis, K.I., Petridis, J. et al.: The role of polymorphisms in 5-HT2c receptor gene in type 2 diabetes mellitus and obesity in the Caucasian population, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 170-173 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
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| Keywords | 5-HT2c receptor gene, type 2 diabetes mellitus, obesity, serotonin. | ||
| Other Terms | Review article | ||
| Summary | 5-HT2C receptor is one of fourteen 5-HT receptor subtypes expressed in the CNS and its gene is located in the X-chromosome (Xq24). Both pharmacological and genetic studies reveal that it contributes substantially to the serotonergic regulation of a wide variety of behavioral and physiological processes such as feeding and glucose homeostasis. Our aim was to determine the possible association of the -759C/T and -697G/C polymorphisms in the promoter region of the 5-HT2C receptor gene with T2DM and obesity in male and female subjects of Caucasian origin. Study population consisted of 151 subjects diagnosed with T2DM and 164 non-diabetic subjects, all of Greek origin. Genomic DNA was extracted from peripheral blood and analysed for the -759C/T and -697G/C polymorphisms of the 5-HT2C receptor gene using PCR-RFLP method. The frequency of T allele of the -759C/T polymorphism of the 5-HT2C receptor was significantly lower in the diabetic group (12.6%) than in the non-diabetic group (23.3%) (p=0.003). The genetic risk of T2DM for subjects not carrying the -759T allele was increased compared to non-diabetic subjects (OR = 2.34, 95% CI = 1.36-4.02). In contrast, the frequency of -759T allele was similar in obese (16.4%) and non-obese (17.1%) subjects. No association of the -697G/C polymorphism with neither T2DM nor obesity was found. The lower frequency of -759T allele of the 5-HT2C receptor gene was associated with T2DM but not with obesity in male and female Caucasians. Thus, -759C/T polymorphism might be indicative of T2DM independently of obesity status. These results, if confirmed by larger studies, indicate that this polymorphism might constitute a useful prognostic marker for T2DM risk. | ||
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Online ISSN 1011-6575
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