| Title | Lanthanum effects on the adult rat brain antioxidant status and adenosinetriphosphatase activities: modulation by L-cysteine | ||
| Authors | Ch. Liapi1, A. Zarros1,2, S. Theocharis3, H. Al-Humadi1, F. Anifantaki1, E. Gkrouzman1, Z. Mellios2, N. Skandali1 and S. Tsakiris2
1. Department of Pharmacology, 2. Department of Physiology and 3. Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece |
||
| Citation | Liapi, C., Zarros, A., Theocharis, S., Al-Humadi, H., Anifantaki, F. et al.: Lanthanum effects on the adult rat brain antioxidant status and adenosinetriphosphatase activities: modulation by L-cysteine, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 221-223 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
||
| Keywords | Lanthanum, L-cysteine, rat, brain, Na+, K+-ATPase, Mg2+-ATPase. | ||
| Other Terms | Review article | ||
| Summary | The aim of this study was to investigate the effect of the antioxidant L-cysteine (Cys, 7mg/kg) on the changes caused by La-administration (as La-chloride, 53mg/kg) on the adult rat brain total antioxidant status (TAS) and the activities of Na+,K+-ATPase and Mg2+-ATPase. Twenty-eight male Wistar rats were divided into four groups: A (saline-treated control), B (La), C (Cys), D (La and Cys). All rats were treated once daily with intraperitoneal injections of the tested compounds, for 1-week. One hour after the last injection, rats were sacrificed by decapitation and whole brain parameters were measured spectrophotometrically. Our findings revealed a partially protective role for Cys towards the oxidative effect of La on the adult rat brain. However, Cys could not (at least under the examined experimental conditions) significantly alter the Na+,K+-ATPase La-induced inhibition, while it further enhanced the Mg2+-ATPase La-induced inhibition. | ||
| References | 1. Hutchison A.J., Speake M., Al-Baaj F.: Reducing high phosphate levels in patients with chronic renal failure undergoing dialysis: a 4-week, dose-finding, open-label study with lanthanum carbonate. Nephrol. Dial. Transplant. 19: 1902-1906 (2004)
2. Guo B.S., Zhu W.M., Xiong B.K., Ji Y.J., Liu Z., Wu Z.M.: Rare Earths in Agriculture. China Agricultural Science and Technology Press, Beijing, p.11. (1990) 3. Goetz L., Bignoli G., Sabbioni E.: Mobilization of heavy metals from coal-fired power plants: potential impact on ground water in quality of groundwater. Stud. Environ. Sci. 17: 261-264 (1982) 4. Noller B.N.: Non-radiological contaminants from uranium mining and milling at ranger, Jabiru, Northern territory, Australia. Environ. Monit. Assess. 19: 383-400 (1991) 5. Noller B.N.: The identification of constituents in waste waters from gold mining using ICP-MS. Int. J. Surface Mining Reclam. Environ. 8: 95-99 (1994) 6. Sabbioni E., Pietra R., Gaglione P., Vocaturo G., Colombo F., Zanoni M.: Long-term occupational risk of rare earth pneumoconiosis. Sci. Total Environ. 26:19-32 (1982) 7. Fan G.Q., Yuan Z.K., Zheng H.L., Liu Z.J.: Study on the effects of exposure to rare earth elements and health-responses in children aged 7-10 years. J. Hyg. Res. 33: 23-28 (2004) 8. Zhu W.F., Xu S.Q., Zhang H., Shao P.P., Wu D.S., Yang W.J., Feng J.: Investigation of children intelligence quotient in REE mining area: bio-effect study of REE mining area in South Jiangxi. Chin. Sci. Bull. 41: 914-916 (1996) 9. Feng L., Xiao H., He X., Li Z., Li F., Liu N., Zhao Y., Huang Y., Zhang Z., Chai Z.: Neurotoxicological consequence of long-term exposure to lanthanum. Toxicol. Lett. 165: 112-120 (2006) 10. Damment S.J.P., De Broe M.E., D’Haese P.C., Bramall N., Cox A.G., McLeod C.W.: Incredulous effects of lanthanum? Toxicol. Lett. 168: 186-189 (2007) 11. EEC Council: EEC Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. Official Journal of the European Union L358: 1-28 (1986) 12. Tsakiris S.: Effects of L-phenylalanine on acetylcholin-esterase and Na+,K+-ATPase activities in adult and aged rat brain. Mech. Ageing Dev. 122: 491-501 (2001) 13. Tsakiris S., Angelogianni P., Schulpis K.H., Behrakis P.: Protective effect of L-cysteine and glutathione on rat brain Na+,K+-ATPase inhibition induced by free radicals. Z. Naturforsch. [C] 55: 271-277 (2000) 14. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275 (1951) 15. Carageorgiou H., Zarros A., Tsakiris S.: Selegiline long-term effects on brain acetylcholinesterase, (Na+,K+)-ATPase activities, antioxidant status and learning performance of aged rats. Pharmacol. Res. 48: 245-251 (2003) 16. Carageorgiou H., Pantos C., Zarros A., Mourouzis I., Varonos D., Cokkinos D., Tsakiris S.: Changes in antioxidant status, protein concentration, acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase activities in the brain of hyper- and hypothyroid adult rats. Metab. Brain Dis. 20: 129-139 (2005) 17. Bowler K., Tirri R.: The temperature characteristics of synaptic membrane ATPases from immature and adult rat brain. J. Neurochem. 23: 611-613 (1974) 18. Zheng H.L., Zhao Z.Q., Zhang C.G., Feng J.Z., Ke Z.L., Su M.J.: Changes in lipid peroxidation, the redox system and ATPase activities in plasma membranes of rice seedling roots caused by lanthanum chloride. BioMetals 13: 157-163 (2000) 19. Li X.M., Ni J.Z., Chen J.W., Hwang F.: Effects of La3+ on lipid fluidity and structural transcyte membranes. Biochem. Mol. Biol. Int. 45: 323-330 (1998) 20. Carageorgiou H., Tzotzes V., Pantos C., Mourouzis C., Zarros A., Tsakiris S.: In vivo and in vitro effects of cadmium on adult rat brain total antioxidant status, acetylcholinesterase, (Na+,K+)-ATPase and Mg2+-ATPase activities: protection by L-cysteine. Basic Clin. Pharmacol. Toxicol. 94: 112-118 (2004) 21. Basu A., Chakrabarty K., Chatterjee G.C.: The effects of lanthanum chloride administration in newborn chicks on glutamate uptake and release by brain synaptosomes. Toxicol. Lett. 20: 303-308 (1984) 22. Sanui H., Rubin H.: The role of magnesium in cell proliferation and transformation. In: (Boynton A.L., McKochan W.L., Whitfield J.P., eds) Ions, Cell Proliferation and Cancer. Pp 517-537, Academic Press, New York, 1982 23. Basu A., Chakrabarty K., Chatterjee G.C.: Neurotoxicity of lanthanum chloride in newborn chicks. Toxicol. Lett. 14: 21-25 (1982) |
||
| Relative Papers | |||
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2008 – ANNUAL SUBSCRIPTION 2008 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|