Τόμος 22 (2008) – Τεύχος 2 – Άρθρο 62 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 22 (2008) – Issue 2 – Article 62 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Adrenal beta-arrestin 1 promotes physiological aldosterone production 
Authors A. Lymperopoulos and W.J. Koch

Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA, 19107

Citation Lymperopoulos, A., Koch, W.J.: Adrenal beta-arrestin 1 promotes physiological aldosterone production, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 224-226 (2008)
Publication Date 23-25 May 2008
Full Text Language English
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Keywords Beta-arrestin, aldosterone production.
Other Terms Review article
Summary Elevated aldosterone levels accompany and aggravate chronic heart failure (HF). Aldosterone is produced by adrenocortical zona glomerulosa (AZG) cells after angiotensin II (AngII) activation of AngII type 1 receptors (AT1Rs), G protein coupled receptors (GPCRs) that also signal independently of G-proteins. This G protein-independent signaling is promoted by βarrestin (βarr) -1 and -2, originally discovered as GPCR signaling terminators. We report here that βarr1 promotes physiological aldosterone production in vivo, in normal rats. These findings suggest adrenal βarr1 inhibition might be of therapeutic value for curbing HF-related hyperaldosteronism.
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