| Title | No association between the cholesteryl ester transfer protein gene-TaqlB polymorphism and coronary restenosis following percutaneous transluminal coronary angioplasty | |
| Authors | S. Kaestner¹, N. Patsouras², C. Flordellis¹ and A. Manolis²
1. Department of Pharmacology, School of Medicine, University of Patras, Greece 2. Regional University General Hospital of Patras, Cardiology Division, Rio, Patras, Greece |
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| Citation | Kaestner, S., Patsouras, N., Flordellis, C., Manolis, A.: No association between the cholesteryl ester transfer protein gene-TaqlB polymorphism and coronary restenosis following percutaneous transluminal coronary angioplasty, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 178-180 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Cholesteryl ester transfer protein, percutaneous transluminal coronary angioplasty, restenosis, TaqlB. | |
| Other Terms | review article | |
| Summary | The most widely studied variation at the cholesteryl ester transfer protein (CETP) gene locus is a silent base change called the TaqlB-polymorphism. TaqlB has been shown to affect levels/activity of CETP and plasma levels of high density lipoprotein cholesterol (HDL-C), and also to contribute to the risk of developing atherosclerosis and coronary heart disease (CHD). The primary objective of this study was to investigate the frequency of TaqlB and a possible association between this polymorphism and restenosis following percutaneous transluminal coronary angioplasty (PTCA) in Greek patients. As a secondary objective, the effect of TaqlB was assessed when accounting for various CHO risk factors, including a deletion in the α2B-adrenergic receptor gene. The frequency of TaqlB in this population was 54%. Either alone or in combination with CHD risk factors, TaqlB was not a significant predictor for assessing the risk of developing coronary restenosis following PTCA. | |
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Online ISSN 1011-6575
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