| Title | Signaling pathways in cancer-induced bone disease and the inhibitory effect of bisphosphonates | |
| Authors | I. Kanakis, X. Stahtea, P.G. Dedes and N.K. Karamanos
Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products,Department of Chemistry, University of Patras, 261 10 Patras, Greece |
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| Citation | Kanakis, I., Stahtea, X., Dedes, P.G., Karamanos, N.K: Signaling pathways in cancer-induced bone disease and the inhibitory effect of bisphosphonates, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 189-191 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Signal transduction, bone metastasis, bisphosphonates. | |
| Other Terms | review article | |
| Summary | Metastatic spread of cancer to bone is a frequent complication in several types of malignancies. Normal bone metabolic process is affected and the imbalance between bone formation and resorption defines bone disease in cancer. Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption that also exhibit antitumor activity. In this article, we describe the osteolytic mechanisms, the signaling pathways which are involved and the inhibitory mode of action of BPs and the results obtained from a pilot study. | |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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